FACE AND HEAD PAIN: EXPERIMENTAL AND CLINICAL STUDIES

面部和头部疼痛：实验和临床研究

• 批准号: 3107834
• 负责人: CHARLES E POLETTI
• 金额: $ 49.34万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107834
• 关键词: neurophysiology; oral facial pain; pain

Pain refractory to routine diagnosis and treatment disables millions of people in the United States, with an estimated annual cost of 70 billion dollars. One of the largest groups disabled by pain consists of people suffering from orofacial and head pains. While this special subgroup remains inadequately studied and treated, recent scientific and technological advances now mandate an investigation focused on the distinctive clinical features of orofacial and head pain and their unique underlying basic mechanisms. We believe our large academic clinical and research hospital is presently particularly well-positioned to provide such an investigation focused on orofacial and head pain. Accordingly, different disciplines within our institution - Neurology, Neurological Surgery, Oral Surgery, Psychiatry, and Anesthesia - are now joined together to propose this integrated multidisciplinary basic and clinical science Program Project. This Program Project proposes four basic scientific animal models focused on the mechanisms subserving intractable orofacial pain. These four models have been designed to study overlapping links of the trigeminal system extending from the peripheral receptors and nerves to the brainstem, thalamus, and somatosensory cortex. Modern extra and intracellular electrophysiology techniques are proposed, along with immunohistochemistry and electron microscopy, to be applied in animal models and postmortem human tissue. These basic studies are aimed at providing fundamental biological clues to the disabling clinical syndromes. The complementing clinical investigation focuses on three syndromes of orofacial pain in adults: trigeminal neuralgia, myofascial orofacial pain, and atypical facial pain. Our hope is that by completing this comprehensive, integrated, and balanced Program Project our multidisciplinary pain group will reach our common goals which are to understand further the mechanisms subserving intractable pain, and thereby to improve health care, especially for people suffering from orofacial pain and headaches.

无法进行常规诊断和治疗的疼痛使人无法工作 美国有数百万人，据估计每年 耗资700亿美元。最大的残疾群体之一 疼痛由遭受口腔面部和头部疼痛的人组成。 虽然这一特殊亚群仍然没有得到充分的研究和 经过治疗，最近的科学技术进步现在 授权对有特色的临床病例进行调查 口面部和头部疼痛的特点及其独特的潜在原因 基本机制。 我们相信我们的大型学术临床和研究医院是 目前特别适合提供这样一种 调查的重点是口腔面部和头痛。因此， 我们机构内的不同学科-神经病学， 神经外科、口腔外科、精神病学和麻醉学- 现在联合起来，提出这一综合的 多学科基础与临床科学计划项目。 该计划项目提出了四个基本的科学动物模型 重点研究了顽固性口腔面部疼痛的机制。 这四个模型旨在研究重叠链接 三叉神经系统从外周感受器延伸 以及神经到脑干、丘脑和躯体感觉皮质。 现代细胞外和细胞内电生理学技术是 建议与免疫组织化学和电子技术一起 显微镜，用于动物模型和身体解剖 人体组织。这些基础研究的目的是提供 致残性临床症状的基本生物学线索。 相辅相成的临床调查重点放在三个方面 成人口面部疼痛症状：三叉神经痛， 肌筋膜口面部疼痛和不典型面部疼痛。 我们希望通过完成这一全面的、综合的、 和平衡计划项目我们的多学科痛点小组 将达到我们的共同目标，即进一步了解 治疗顽固性疼痛的机制，从而改善 医疗保健，尤其是对口腔面部疼痛患者的保健 还有头痛。