HIGH-DOSE CRANIAL IRRADIATION ON GROWTH HORMONE AND PROLACTIN IN CHILDREN

高剂量颅脑照射对儿童生长激素和催乳素的影响

• 批准号: 3904491
• 负责人: CHARLES SKLAR
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3904491
• 关键词: child (0-11); head /neck neoplasm; human subject; human therapy evaluation; pediatric neoplasm /cancer; prolactin; radiation therapy dosage; radiobiology; sleep; somatotropin

In addition to standard provocative testing in children prior to radiation therapy, 6-12 months post-irradiation and yearly as indicated by the patient's clinical course, this study will assess growth hormone secretion during sleep. It involves serial blood sampling every 20 min for 8 h followed by metaclopramide stimulation test for both growth hormone and prolactin.

除了在儿童中进行标准的刺激性测试之外， 放射治疗，照射后6-12个月，每年一次，如有指征 根据患者的临床病程，本研究将评估生长激素 睡眠时的分泌物。它包括每20分钟连续采血一次 8 h，然后进行甲氯普胺刺激试验， 激素和催乳素。