EFFECTS OF SEX STEROIDS ON GROWTH HORMONE CONCENTRATIONS

性类固醇对生长激素浓度的影响

• 批准号: 6122557
• 负责人: CHARLES SKLAR
• 金额: $ 12.81万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6122557
• 关键词: antineoplastics; clinical research; combination cancer therapy; drug adverse effect; hormone regulation /control mechanism; human puberty; human subject; leukemia; lymphoma; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; pediatric neoplasm /cancer; sex hormones; somatotropin

We will test the hypothesis that the therapies currently employed to treat childhood leukemias and lymphomas (systemic/intrathecal chemotherapy and lwo-dose, 1800cGy, cranial radiation) cause damage to the neuroregulatory centers int he brain responsible for the sex steroid mediated increase in growth hormone production. As a consequence, these individuals produce normal amounts of GH in the prepubertal years but fail to demonstrate the expected increase in GH concentration in response to sex steroids (both endogenous and exogenous).

我们将检验一种假设，即目前用于治疗 儿童白血病和淋巴瘤（全身/鞘内化疗和 lwo-dose，1800cGy，颅辐射）引起神经调节损伤 大脑中负责性类固醇介导的 生长激素的产生。 因此，这些个体产生 正常量的生长激素在青春期前几年，但未能证明 预期GH浓度增加响应性类固醇（两者 内源性和外源性）。