RIMANTIDINE TREATMENT OF ACUTE INFLUENZA A VIRUS INFECTION

金刚乙胺治疗急性甲型流感病毒感染

• 批准号: 3905724
• 负责人: STEPHEN B GREENBERG
• 金额: --
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3905724
• 关键词: acute disease /disorder; aerosols; amantadine; antiviral agents; drug administration routes; drug adverse effect; drug tolerance; human subject; human therapy evaluation; influenza; respiratory infections

Part I of this study, being done in the GCRC, is examining the safety, tolerance, and pharmacokinetics of rimatiadine by small particle aerosol. Part II of the study is an efficacy study. It will be a double -blind, placebo-controlled comparison of rimantadine by small particle aerosol. Part II of the study is an efficacy study. It will be a double-blind, placebo-controlled comparison of rimantadine by mouth and small particle aerosol in the treatment of acute influenza A virus infection.

这项研究的第一部分，在GCRC进行，是检查安全性， 耐受性和小颗粒气雾剂的药代动力学。 本研究的第二部分是疗效研究。是双盲的， 金刚乙胺小颗粒气雾剂的安慰剂对照比较。 本研究的第二部分是疗效研究。这将是一个双盲， 金刚乙胺口服与小颗粒口服安慰剂对照研究 气雾剂治疗急性甲型流感病毒感染。