ANTISERA AND RECOMBINANT PROTEINS FOR RESEARCH IN AIDS

目的：抗病毒药物和疫苗的发展 有效对抗艾滋病毒的药物的缺乏阻碍了 标准化试剂。这样的试剂对于 以下：识别免疫所需的病毒表位， 描述对感染和免疫反应的性质 免疫接种，以促进改进方法的发展 监测正在接受治疗的患者的病毒载量， 描述抗原漂移的程度和意义 在艾滋病毒和相关逆转录病毒中发生，并建立动物 艾滋病的模特。这次征集的目的是为了支持 提供这些试剂所需的研究活动和供应 AIDSP分发给科学工作者的试剂 社区。 这次征集的目的是克隆基因，表达 从基因中提取功能蛋白，并制作抗这些蛋白的血清 蛋白质。根据本合同生产的产品将用于 支持科学界的研究活动。 这些试剂的一些试剂存在于政府内部， 学术和工业实验室，但NIAID需要一个集中的 生产资源要满足科学化的需要 社区。NIAID需要获得大量的 支持国家的努力的著名材料 合作药物发现小组，国家疫苗 发展小组、艾滋病临床研究小组、 爱滋病基础研究卓越计划及其他 由NIAID发起的更具体的计划。

OBJECTIVE: The development of antiviral drugs and vaccines effective against HIV has been hampered by the absence of standardized reagents. Such reagents are necessary for the following: to identify viral epitopes required for immunity, to characterize the nature of the immune response to infection and immunization, to facilitate the development of improved methods to monitor viral load in patients undergoing treatment, to characterize the extent and significance of antigenic drift as it occurs in HIV and related retroviruses, and to establish animal models of AIDS. It is the purpose of this solicitation to support research activities needed to provide these reagents and to supply reagents to the AIDSP for distribution to the scientific community. It is the purpose of this solicitation to clone genes, express functional proteins from the genes and make antisera to those proteins. The products produced under this contract will be used to support the research activities of the scientific community. Some reagents of these reagents exist within government, academic and industry laboratories, but NIAID needs a centralized production resource to meet the needs of the scientific community. The NIAID needs access to significant quantities of the noted materials to support the efforts of the National Cooperative Drug Discovery Groups, the National Vaccine Development Groups, the AIDS Clinical Study Groups, the Programs of Excellence in Basic Research on AIDS, and other more specific programs initiated by NIAID.