DEVELOPMENT OF RADIATION SNYOVECTOMY IN RHEUMATOID ARTHRITIS

类风湿性关节炎放射治疗的进展

• 批准号: 3907473
• 负责人: CLEMENT B SLEDGE
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3907473
• 关键词: articular cartilage; beta radiation; human subject; human therapy evaluation; injection /infusion; joint disorder; knee; radionuclide therapy; rheumatoid arthritis; synovitis

Radiation synovectomy produces functional ablation of inflamed synovium following intra-articular administration of short range, beta-emitting radio-isotopes. The isotope is complexed to a particular carrier in order to delay and decrease leakage from the joint and thereby reduce the total body radiation exposure. The overall objective of this protocol is to improve the clinical utility of radiation synovectomy in the treatment of rheumatoid synovitis and develop appropriate means to assess the effect of treatment.

放射滑膜切除术可对发炎滑膜进行功能性消融 关节内注射短程、发射β的药物后 放射性同位素。同位素与特定载体络合，以便 延迟和减少接头泄漏，从而减少总泄漏量 身体辐射暴露。该协议的总体目标是 提高放射滑膜切除术治疗滑膜切除术的临床效用 类风湿性滑膜炎并制定适当的方法来评估效果 的治疗。