THE DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITIS

关节炎放射滑膜切除术的进展

• 批准号: 3157403
• 负责人: CLEMENT B SLEDGE
• 金额: $ 26.62万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3157403
• 关键词: allergic arthritis; articular cartilage; bioassay; disease /disorder model; histopathology; human subject; human therapy evaluation; musculoskeletal disorder diagnosis; radiation therapy dosage; radiobiology; radiological health; radionuclide imaging /scanning; radionuclide therapy; radiopharmacology; rheumatoid arthritis; skeletal pharmacology; thermometry

Radiation synovectomy produces functional ablation of the inflamed synovium by the intra-articular administration of short-range, beta-emitting isotopes in particulate form to delay leakage from the joint and undesirable distant effects. We have developed a new isotope-particle system, dysprosium-165-ferric hydroxide macroaggregate (165Dy-FHMA), and have demonstrated extremely low levels of leakage from animal and human joints. Clinical trials of effectiveness in humans are underway. We propose to continue clinical trials with Dy-FHMA to establish the effectiveness of this agent in reducing pain, swelling and inflammation in rheumatoid arthritis. Other isotopes and other carrier systems will be evaluated to provide increased availablility, widened spectrum of tissue penetration for use in various joints, and new carriers to retain the administered isotope with the joint. Liposomes, albumin microspheres, nd colloids will be examined as well as continued investigation of the usefulness of FHMA with other isotopes. Essential to the demonstration of usefulness of these techniques is the development of objective means of assessing joint inflammation before and after treatment. In animals, antigen-induced arthritis will be used as a model of rheumatoid arthritis and the effect of treatment measured by determination of synovial production of the newly described messenger molecule catabolin. In both animals and humans, external measurement of joint temperature using thermography will be compared with radionuclide scans using (99m)Tc compounds.

放射性滑膜切除术产生功能性消融的发炎滑膜 通过关节内注射短程β-发射 微粒形式的同位素，以延迟接头泄漏， 不良的远距离影响。 我们开发了一种新的同位素粒子 系统，镝-165-氢氧化铁大团聚体（165 Dy-FHMA），和 已经证明从动物和人类的泄漏水平极低 接头. 人体有效性的临床试验正在进行中。 我们 建议继续进行Dy-FHMA的临床试验，以确定 这种药物在减轻疼痛、肿胀和炎症方面的有效性， 类风湿关节炎 其他同位素和其他载体系统将 评估以提供更高的可用性、更宽的组织谱 用于各种关节的穿透，以及用于保持 在关节处注射同位素 脂质体，白蛋白微球，ND 将检查胶体以及继续调查的 FHMA与其他同位素的用途。 对于证明 这些技术的有用性是客观手段的发展， 评估治疗前后的关节炎症。 在动物中， 抗原诱导的关节炎将被用作类风湿性关节炎的模型 并通过测定滑膜细胞来测量治疗效果， 新描述的信使分子分解代谢素的产生。 无论是 动物和人类，使用外部测量关节温度 热成像将与使用（99 m）Tc的放射性核素扫描进行比较 化合物.