THE DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITIS

放射性滑膜切除术对炎症的滑膜进行功能性消融 通过关节内注射短程的β-射线 以颗粒状形式存在的同位素可延缓接缝和 令人不快的远距离影响。我们已经开发出一种新的同位素粒子 体系，镝-165-氢氧化铁大聚集体(165Dy-FHMA)，以及 已经显示出极低的动物和人类渗漏水平 关节。人体有效性的临床试验正在进行中。我们 建议继续使用Dy-FHMA进行临床试验，以建立 该药对小鼠的止痛、消肿、消炎作用 类风湿关节炎。其他同位素和其他载体系统将 评估以提供更高的可用性、更宽的组织频谱 用于各种接头的穿透性，以及用于保持 在关节处注射了同位素。脂质体，白蛋白微球，ND 将对胶体进行检查，并继续调查 FHMA与其他同位素的有用性。对演示的关键 这些技术的有用性是客观手段的发展 评价治疗前后关节炎症情况。在动物身上， 抗原诱导的关节炎将被用作类风湿性关节炎的模型 通过测定滑膜厚度来衡量治疗效果 新描述的信使分子分解代谢的产生。在这两个地方 动物和人类关节温度的外部测量 热成像将与使用(99m)Tc的放射性核素扫描进行比较 化合物。

Radiation synovectomy produces functional ablation of the inflamed synovium by the intra-articular administration of short-range, beta-emitting isotopes in particulate form to delay leakage from the joint and undesirable distant effects. We have developed a new isotope-particle system, dysprosium-165-ferric hydroxide macroaggregate (165Dy-FHMA), and have demonstrated extremely low levels of leakage from animal and human joints. Clinical trials of effectiveness in humans are underway. We propose to continue clinical trials with Dy-FHMA to establish the effectiveness of this agent in reducing pain, swelling and inflammation in rheumatoid arthritis. Other isotopes and other carrier systems will be evaluated to provide increased availablility, widened spectrum of tissue penetration for use in various joints, and new carriers to retain the administered isotope with the joint. Liposomes, albumin microspheres, nd colloids will be examined as well as continued investigation of the usefulness of FHMA with other isotopes. Essential to the demonstration of usefulness of these techniques is the development of objective means of assessing joint inflammation before and after treatment. In animals, antigen-induced arthritis will be used as a model of rheumatoid arthritis and the effect of treatment measured by determination of synovial production of the newly described messenger molecule catabolin. In both animals and humans, external measurement of joint temperature using thermography will be compared with radionuclide scans using (99m)Tc compounds.