Delving deeper into the Matrix: Redefining the Extracellular Matrix in Cancer Treatment

深入研究基质：重新定义癌症治疗中的细胞外基质

• 批准号: nhmrc : GNT1158590
• 负责人: Dr Thomas Cox
• 金额: $ 48.34万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/delving-deeper-matrix-cancer-treatment/1349264
• 关键词: Delving; deeper; into; Matrix; Redefining

Cancer growth and spread is strongly affected by the extracellular matrix (ECM). The ECM is the mesh or glue that surrounds cells in our organs. The ECM is fundamentally changed in cancer vs. normal tissue, and has a huge impact on how cancer cells behave. Our mission is to: 1) Develop innovative laboratory tools that better mimic the cancer ECM 2) Deepen our understanding of how cancer ECM contributes to treatment failure and resistance: 3) Develop new combination therapies that target the ECM.

肿瘤的生长和扩散受到细胞外基质（ECM）的强烈影响。ECM是包围我们器官中细胞的网或胶。ECM在癌症与正常组织中发生了根本性的变化，对癌细胞的行为产生了巨大的影响。我们的使命是：1）开发更好地模拟癌症ECM的创新实验室工具2）加深我们对癌症ECM如何导致治疗失败和耐药性的理解：3）开发针对ECM的新组合疗法。