Computed microscopy: solving the inverse problem of optical microscopy to image deeper into biological tissue

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This project aims to enable 3D optical microscopy to image deeper within tissue, ultimately aiding research fields such as neurobiology. This will be achieved by a foundational approach called computed cicroscopy that combines novel numerical methods, high performance computing and optical microscopy. This project aims to develop a 3D quantitative imaging method that will provide unprecedented insight into the structure of tissue with sub-cellular detail. This information can then be used to computationally reverse light scattering within the sample, allowing fluorescence microscopy at unprecedented depths within tissue.