Reversing the biomechanical dysregulation of cancer cell signalling to improve targeted therapies

逆转癌细胞信号传导的生物力学失调以改善靶向治疗

• 批准号: nhmrc : GNT1129766
• 负责人: Dr Thomas Cox
• 金额: $ 66.34万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reversing-biomechanical-dysregulation-targeted-therapies/1347773
• 关键词: Reversing; biomechanical; dysregulation; cancer; cell

The limited success of cancer drugs is dependent on many factors including the physical properties (stiffness) of a tumour. In particular whether a tumour is soft or stiff affects how it responds to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology, we will determine how we can target the physical properties of tumours together with already approved cancer drugs to improve treatment and patient outcome.

抗癌药物的有限成功取决于许多因素，包括肿瘤的物理特性(僵硬)。特别是，肿瘤是软的还是硬的会影响它对治疗的反应。将经典生物学与工程学相结合，生成模拟肿瘤的3D模型，以及尖端成像技术，我们将确定如何将肿瘤的物理属性与已经批准的抗癌药物一起靶向，以改善治疗和患者结果。