Dementia associated to diabetes: prevention through the modulation of cerebrovascular integrity

与糖尿病相关的痴呆：通过调节脑血管完整性来预防

• 批准号: nhmrc : GNT1135590
• 负责人: A/Pr Ryusuke Takechi
• 金额: $ 71.98万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Boosting Dementia Research Initiative
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dementia-associated-diabetes-cerebrovascular-integrity/1347983
• 关键词: Dementia; associated; diabetes; prevention; through

Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.

据报道，糖尿病胰岛素抵抗可引起认知能力下降和痴呆。越来越多的证据表明，受损的神经血管单位的完整性和脑脂质稳态的变化可能是中央参与神经退行性病变和认知功能障碍。因此，该项目旨在通过调节血管系统的完整性和脂质稳态来预防胰岛素抵抗相关的认知障碍。