The Beaver Dam Offspring Study Neurocognitive Aging Study (BOSS-NCAS)-A Study on the Role of Accelerated Aging and Midlife Sensory Decline for Early Alzheimer’s Disease and Dementia in Later Life

海狸坝后代研究神经认知衰老研究 (BOSS-NCAS) - 加速衰老和中年感觉衰退对早期阿尔茨海默病和晚年痴呆的作用研究

• 批准号: 10525122
• 负责人: Natascha Merten
• 金额: $ 77.56万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525122
• 关键词: Adult; Age; Age-Years; Aging; Alzheimer associated neurodegeneration; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Auditory; Beavers; Biological; Biological Aging; Biological Markers; Blood; Blood Vessels; Blood specimen; Caregivers; Chronic; Chronology; Clinical; Cognition; Cohort Studies; Consensus; Contrast Sensitivity; Data; Dementia; Diabetes Mellitus; Diagnosis; Digit structure; Disease; Early Diagnosis; Elderly; Environmental Risk Factor; Etiology; Evaluation; Future; General Population; Hearing; Hearing Tests; Heart Diseases; Impaired cognition; Impairment; Individual; Inflammation; Interview; Longitudinal cohort study; Longterm Follow-up; Measures; Medical History; Medical Records; Metabolic; Methods; Morbidity - disease rate; Nephrosis; Nerve Degeneration; Neurocognitive; Odors; Ophthalmic examination and evaluation; Otoscopy; Participant; Pathologic; Pathway interactions; Persons; Pharmaceutical Preparations; Phenotype; Physiological; Predictive Value; Protocols documentation; Questionnaires; Renal function; Research; Risk; Role; Screening procedure; Sensory; Smell Perception; Standardization; Taste Perception; Testing; Time; Trail Making Test; Verbal Learning; Vision; Visit; Visual Acuity; age related; aging brain; base; blood-based biomarker; cardiovascular risk factor; cognitive change; cognitive function; cognitive testing; cohort; cost effective; dementia risk; disability risk; early detection biomarkers; epidemiology study; follow-up; glucose metabolism; high risk; lifestyle factors; liver function; mental state; middle age; mortality; multidisciplinary; novel; offspring; pre-clinical; prevent; prospective; response; symposium; tau Proteins; tau-1

ABSTRACT The purpose of this epidemiologic study is to determine if sensory changes (hearing, vision, olfaction) and an emerging biomarker of aging (PhenoAge) measured in midlife are strong predictors of long-term risk for early Alzheimer’s disease and related dementias (ADRD), and to study the shared etiology of co-occurring sensory and cognitive changes. Subjects are previous participants in a prospective longitudinal cohort study, the Beaver Dam Offspring Study (BOSS) and were 21-84 years of age at the baseline examination (2005-2008). The proposed study (BOSS–Neurocognitive Aging Study) will apply standardized protocols used in the BOSS baseline, 5-year and 10-year follow-up examinations including a hearing evaluation (otoscopy, audiometry and word recognition in quiet and in competing message), eye examination (refraction, visual acuity and contrast sensitivity) and olfaction testing (San Diego Odor Identification Test) and conduct an extended cognitive test battery (Trail Making Test, Auditory Verbal Learning Test, Verbal Fluency Test, Digit Symbol Substitution Test, Digit Span, Stroop Test, Mini-Mental State Examination). We will further enhance the evaluation of early ADRD status by incorporating medical records, caregiver interviews and blood-based biomarkers of AD and neurodegeneration (amyloid b40, amyloid b42, total Tau and phosphorylated Tau) in a clinical review that will be conducted by a multidisciplinary neurocognitive expert panel in a diagnosis consensus conference. Cardiovascular risk factors will be assessed and standardized questionnaires on medical history, medication usage and lifestyle and environmental factors will be completed. We will measure longitudinal changes in PhenoAge using new and stored baseline blood samples. The proposed epidemiological study will provide important information about early biomarkers for the risk of developing cognitive decline and early ADRD and will inform about relationships between changes in sensory and cognitive function. This will contribute to developing clinically useful methods to identify high-risk people in midlife and to understanding the shared etiologies of sensory and cognitive changes. This project’s results will inform about potential pathways for prevention of ADRD and the promotion of healthy brain aging.

摘要 这项流行病学研究的目的是确定是否感觉变化（听力，视力，嗅觉）和 在中年测量的新兴衰老生物标志物（PhenoAge）是早期衰老长期风险的强有力预测因素。 阿尔茨海默氏病和相关痴呆（ADRD），并研究共同发生的感觉 和认知变化。受试者是一项前瞻性纵向队列研究的既往参与者， 比弗坝后代研究（BOSS）中，基线检查时年龄为21-84岁（2005-2008年）。 拟议的研究（BOSS-神经认知老化研究）将采用BOSS中使用的标准化方案 基线、5年和10年随访检查，包括听力评估（耳镜检查、测听和 在安静和竞争信息中的单词识别）、眼睛检查（屈光、视力和对比度 灵敏度）和嗅觉测试（圣地亚哥气味识别测试），并进行扩展认知测试 成套测验（连线测验，听觉语言学习测验，语言流畅性测验，数字符号替换测验， 数字广度、Stroop测验、简易精神状态检查）。我们将进一步加强对早期ADRD的评估 通过纳入医疗记录、护理人员访谈和基于血液的AD生物标志物， 神经变性（淀粉样蛋白b40，淀粉样蛋白b42，总Tau和磷酸化Tau）的临床综述， 由多学科神经认知专家小组在诊断共识会议上进行。 将评估心血管危险因素，并对病史、药物治疗 使用和生活方式和环境因素将完成。我们将测量 PhenoAge使用新的和储存的基线血液样本。拟议的流行病学研究将提供 关于发生认知能力下降和早期ADRD风险的早期生物标志物的重要信息， 将告知感觉和认知功能变化之间的关系。这将有助于 开发临床上有用的方法来识别中年高风险人群，并了解 感觉和认知变化的病因学。该项目的结果将告知潜在的途径， 预防ADRD和促进健康的大脑衰老。