Restoration of cognitive deficits induced by diabetes through the modulation of cerebrovascular integrity

通过调节脑血管完整性恢复糖尿病引起的认知缺陷

• 批准号: nhmrc : GNT1106613
• 负责人: A/Pr Ryusuke Takechi
• 金额: $ 26.13万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/restoration-cognitive-deficits-cerebrovascular-integrity/1346527
• 关键词: Restoration; cognitive; deficits; induced; diabetes

Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.

众所周知，糖尿病是导致痴呆的危险因素。然而，这种联系的细节尚不清楚。最近的证据一致表明，大脑血管的完整性可能是痴呆症发病的核心，并且在糖尿病患者和动物模型中经常报道血管受损。这个项目是第一个以恢复这些脑血管的完整性为目标，以逆转糖尿病相关的痴呆。