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RECEPTOR MEDIATED T CELL ACTIVATION

RECEPTOR MEDIATED T CELL ACTIVATION
受体介导的 T 细胞激活
批准号:
3939369
负责人:
R J HODES
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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英文摘要
The mechanism of T cell activation has been studied employing both cloned T cell populations and naive heterogeneous T cell populations. Comparison has been made of T cell stimulation by antibodies directed to allotypic determinants on the T cell receptor, T cell activation by specific antigen, and T cell activation by non-receptor-mediated signaling. It has been demonstrated that both cloned and naive T cells can be triggered by the monoclonal antibody F23.1, directed toward determinants on the T cell receptor. Naive Lyt2+ T cells were activated to proliferate in the presence of soluble F23.1, IL-2, and accessory cells. Under the same conditions, L3T4+ naive T cells were unresponsive. These findings thus demonstrated a difference in the activation requirements of T cell subpopulations triggered through T cell receptor determinants. Specific "targeting" of the T cell receptor to accessory cell structures by heteroaggregates of F23.1 coupled to monoclonal anti-Ia antibody were, in contrast, capable of activating both Lyt2+ and L3T4+ T cell subpopulations. The nature of activation signals provided under these diverse conditions is currently under study. In particular, the function of endogenous lymphokines is being analyzed. Parameters of T cell response including specific gene activation and exocytosis of cytoplasmic granules in response to diverse stimuli have been evaluated.
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REGULATION OF LYMPHOCYTE PROLIFERATION AND CELL CYCLE PROGRESSION
T CELL REGULATION AND B CELL ACTIVATION
RECEPTOR MEDIATED T AND B CELL ACTIVATION
IMMUNE RESPONSE GENE REGULATION OF IMMUNE RESPONSE IN VITRO
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