Dendritic cell function, migration and modulation in a murine model of inflammatory arthritis

炎症性关节炎小鼠模型中树突状细胞的功能、迁移和调节

• 批准号: nhmrc : 102513
• 负责人: Prof Ranjeny Thomas
• 金额: $ 13.46万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dendritic-cell-function-inflammatory-arthritis/83141
• 关键词: Dendritic; cell; function; migration; modulation

Rheumatoid arthritis (RA) is a debilitating disease that affects the joints and other tissues. While it can often be controlled with drugs, complete remission off treatment is rare. Dendritic cells are the educators of the immune system. By displaying antigen to T cells they communicate the response that the immune system should make to foreign organisms, tumors and to self. Therefore, a communication failure may result in chronic inflammation, tumor growth or autoimmune disease, such as RA. In this proposal, we focus on the role of dendritic cells in a mouse model of RA and explore ways of using dendritic cells to turn off disease, that if successful may translate in humans to induction of remission.

类风湿性关节炎 (RA) 是一种影响关节和其他组织的衰弱性疾病。虽然通常可以通过药物控制，但治疗后完全缓解的情况很少见。树突状细胞是免疫系统的教育者。通过向 T 细胞展示抗原，它们传达免疫系统应对外来生物体、肿瘤和自身做出的反应。因此，沟通失败可能会导致慢性炎症、肿瘤生长或自身免疫性疾病，例如 RA。在这项提案中，我们重点关注树突状细胞在 RA 小鼠模型中的作用，并探索使用树突状细胞来关闭疾病的方法，如果成功，可能会在人类中转化为诱导缓解。