Migration and differentiation of dendritic cells and monocytes in inflammatory arthritis.

炎性关节炎中树突状细胞和单核细胞的迁移和分化。

• 批准号: nhmrc : 252879
• 负责人: Prof Ranjeny Thomas
• 金额: $ 18.67万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/migration-differentiation-dendritic-inflammatory-arthritis/98369
• 关键词: Migration; differentiation; dendritic; cells; monocytes

Dendritic cells and monocytes are of critical importance to the development and persistence of inflammatory disease in rheumatoid arthritis. Blocking this process at key strategic intervention points is a major focus of research to improve disease treatment. These studies examine the critical processes and molecules that control the entry of these cells to the joint in mice, and the derivation of cells that contribute directly to bone damage in the disease.

树突状细胞和单核细胞对类风湿关节炎炎症性疾病的发展和持续至关重要。在关键的战略干预点阻断这一过程是改善疾病治疗的研究重点。这些研究检查了控制这些细胞进入小鼠关节的关键过程和分子，以及直接导致疾病中骨损伤的细胞的来源。