Migration and differentiation of dendritic cells and monocytes in inflammatory arthritis.

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Dendritic cells and monocytes are of critical importance to the development and persistence of inflammatory disease in rheumatoid arthritis. Blocking this process at key strategic intervention points is a major focus of research to improve disease treatment. These studies examine the critical processes and molecules that control the entry of these cells to the joint in mice, and the derivation of cells that contribute directly to bone damage in the disease.