Understanding the basis of autoimmunity in rheumatoid arthritis and type 1 diabetes to underpin the implementation of antigen-specific therapies

点击翻译按钮获取中文摘要

In autoimmune diseases chronic organ-specific or systemic inflammation has devastating and destructing consequences. In rheumatoid arthritis (RA) and type 1 diabetes (T1D), HLA contribute the major genetic susceptibility. HLA proteins present the antigens which underlie disease development. This proposal underpins my vision for development of antigen-specific therapy in RA and T1D, examining interaction between HLA molecules and antigen and disease, and risk markers for T1D development.