Understanding the basis of autoimmunity in rheumatoid arthritis and type 1 diabetes to underpin the implementation of antigen-specific therapies

了解类风湿关节炎和 1 型糖尿病自身免疫的基础，以支持抗原特异性疗法的实施

• 批准号: nhmrc : 1079238
• 负责人: Prof Ranjeny Thomas
• 金额: $ 56.51万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-basis-autoimmunity-specific-therapies/518647
• 关键词: Understanding; basis; autoimmunity; rheumatoid; arthritis

In autoimmune diseases chronic organ-specific or systemic inflammation has devastating and destructing consequences. In rheumatoid arthritis (RA) and type 1 diabetes (T1D), HLA contribute the major genetic susceptibility. HLA proteins present the antigens which underlie disease development. This proposal underpins my vision for development of antigen-specific therapy in RA and T1D, examining interaction between HLA molecules and antigen and disease, and risk markers for T1D development.

在自身免疫性疾病中，慢性器官特异性或全身性炎症具有毁灭性和破坏性的后果。在类风湿性关节炎 (RA) 和 1 型糖尿病 (T1D) 中，HLA 是主要的遗传易感性。 HLA 蛋白呈递导致疾病发展的抗原。该提案支撑了我开发 RA 和 T1D 抗原特异性疗法的愿景，检查 HLA 分子与抗原和疾病之间的相互作用，以及 T1D 发展的风险标记。