KETONE FALSE-POSITIVES WITH THE DRUG MESNA AND OTHER FREE-SULFHYDRYL COMPOUNDS

酮与药物美司钠和其他游离巯基化合物的误报

• 批准号: 3916526
• 负责人: G CSAKO
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916526
• 关键词: acetoacetates; acetone; clinical chemistry; human tissue; ketones; nitroferricyanide

The Legal test (acetoacetic acid and/or acetone and sodium nitroprusside in alkaline medium) was studied for interference with the uroprotective drug mesna and related compounds. All free- sulfhydryl compounds tested produced false-positive reactions in this test for ketones. The presence of acidic groups in the structure appeared to increase the nitroprusside reactivity of free sulfhydryl compounds, whereas the presence of an amino group appeared to decrease it. Procedures have been elaborated to recognize and rule out false-positive ketone reactions with these compounds in clinical specimens.

法律的试验（乙酰乙酸和/或丙酮和钠 硝普钠在碱性介质中）的干扰进行了研究， 尿保护药物美司钠和相关化合物。 全部免费- 测试的巯基化合物产生假阳性 在这个测试中，酮的反应。 酸性物质的存在 结构中的基团似乎增加了硝普钠 游离巯基化合物的反应性，而存在的 氨基似乎可以降低它。 详细说明以识别和排除假阳性酮 与临床标本中的这些化合物发生反应。