GC-MS ANALYSIS OF PCDF BLOOD LEVELS IN CHILDREN EXPOSED IN VITRO

已经有两起多氯联苯中毒事件 联苯（FCB）及其热分解产物;首先， 1968年在日本，1979年在台湾。 因为PCB是 一个世界范围的污染问题，这些事件已经被研究 仔细，因为他们提供了唯一的机会， 直接观察多氯联苯对人体的毒性， 职场 评价这些的实验室方法 1968年的疫情相对简单; 分析方法的巨大进步。 协同 台湾科学家，流行病学分支，NIEHS， 有机会检查100多名在子宫内的儿童， 1979年中毒事件发生时或之后 这些孩子 继续受到影响，因为化学品不能排出体外， 从母亲的身体。 在一项合作努力中，质谱仪将 分析大约120份血清样本的四，五， 六氯二苯并呋喃的含量为万亿分之一。 我们有 目前已验证提取程序和分析 样品将于1989财政年度开始。

There have been two outbreaks of human poisoning by polychlorinated biphenyls (FCBs) and their thermal breakdown products; the first, in Japan in 1968, the second in Taiwan in 1979. Because PCBs are a world wide pollution problem, these episodes have been studied carefully, since they have presented the only opportunity to observe directly the toxicity of PCBs in human beings outside the workplace. Laboratory methods for the evaluation of these outbreaks were relatively unsophisticated in 1968; there has been great progress in analytical methods since. In collaboration with Taiwanese scientists, the Epidemiology Branch, NIEHS, had the opportunity to examine over 100 children who had been in utero at the time of the 1979 poisoning or afterward. These children continued to be affected, since the chemicals cannot be excreted from the mother's body. In a collaborative effort, the mass spectrometry workgroup will analyze approximately 120 serum samples for tetra-, penta- and hexachlorodibenzofurans at the part per trillion level. We have currently validated the extraction procedure and analysis of the samples will commence in FY 1989.