EFFECT OF HYPOTHERMIA ON MYOCARDIAL TISSUE PH DURING CARDIOPULMONARY BYPASS

体外循环过程中低温对心肌组织pH值的影响

• 批准号: 3920093
• 负责人: R C ROBBINS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920093
• 关键词: acid base balance; acidity /alkalinity; heart /lung bypass; heart metabolism; human subject; induced hypothermia; myocardial ischemia /hypoxia; robotics

The effect of hypothermia on intracellular myocardial pH in humans is unknown. The acid-base status of blood during systemic hypothermia theoretically should have profound effects on myocardial tissue pH. Variations in myocardial tissue pH affect enzyme function and the ability of the organ to withstand ischemia. The purpose of this project is to determine whether myocardial pH varies with changes in blood pH. The NIH tissue pH probe has been inserted in the myocardium of 16 patients during hypothermic cardiopulmonary bypass. The acid-base scheme followed was either that of alpha-stat (N=3) or pH-stat (N=ll) and the tissue pH was compared to that of the myocardium using these two pH management schemes. Two patients had inadequate data. The preliminary results show that the changes in myocardial pH parallel those of the blood pH. The study is to continue.

低温对人心肌细胞内pH值的影响 不明 全身麻醉期间血液酸碱状态 低温理论上会对 心肌组织pH值的变化影响 酶的功能和器官抵抗局部缺血的能力。 本项目的目的是确定心肌pH值是否 随着血液pH值的变化而变化。 NIH组织pH探针已插入16例心肌 低温体外循环期间的患者。 酸碱 随后的方案是alpha-stat（N=3）或pH-stat （N= 11），并将组织pH值与心肌的pH值进行比较 使用这两种pH值管理方案。 2例患者数据不足。 初步结果表明 心肌pH值的变化与血液pH值的变化平行。 这项研究将继续进行。