EFFECT OF HYPOTHERMIA ON MYOCARDIAL TISSUE PH DURING CARDIOPULMONARY BYPASS

体外循环过程中低温对心肌组织pH值的影响

• 批准号: 3942876
• 负责人: R C ROBBINS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942876
• 关键词: acid base balance; acidity /alkalinity; heart /lung bypass; heart metabolism; human subject; induced hypothermia; myocardial ischemia /hypoxia; robotics

The effect of hypothermia on intracellular myocardial pH in humans is unknown. The acid-base status of blood during systemic hypothermia theoretically should have profound effects on myocardial tissue pH. Variations in myocardial tissue pH affect enzyme function and the ability of the organ to withstand ischemia. The purpose of this project is to determine whether myocardial ph varies with changes in blood pH. The NIH tissue pH probe has been inserted in the myocardium of 16 patients during hypothermic cardiopulmonary bypass. The acid-base scheme followed was either that of alpha-stat (N=3) or pH-stat (N=11) and the tissue pH was compared to that of the myocardium using these two pH management schemes. Two patients had inadequate data. The preliminary results show that the changes in myocardial pH parallel those of the blood pH. Additionally, the pH-stat scheme appears to result in a small elevation of pH such that the myocardium is acidotic during hypothermia. The study is to continue.

低温对心肌细胞内pH的影响 人类未知。 全身麻醉期间血液酸碱状态 低温理论上会对 心肌组织pH值的变化影响 酶的功能和器官承受 缺血 该项目的目的是确定是否 心肌pH随血液pH的变化而变化。 NIH组织pH探针已插入心肌中， 16例患者在低温体外循环期间。 的 遵循的酸碱方案为α-stat（N=3）或 pH-stat（N=11），并将组织pH值与 心肌使用这两个pH值管理方案。 两 患者数据不足。 初步结果显示， 心肌pH值的变化与血液pH值的变化平行。 此外，pH-stat方案似乎导致小的 pH值升高，使心肌酸中毒 体温过低 这项研究将继续进行。