The gut-sleep-brain axis: Targeting the gut microbiota and sleep quality by individualized non-pharmaceutical approaches to promote healthy ageing

肠道-睡眠-大脑轴：通过个体化非药物方法针对肠道微生物群和睡眠质量，促进健康老龄化

• 批准号: ES/W006367/1
• 负责人: Alpar Lazar
• 金额: $ 6.42万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FW006367%2F1
• 关键词: gut; sleep; brain; axis; Targeting

Our ultimate vision is to develop an intelligent sleep enhancement platform (ISEP) that would ultimately target the promotion of healthy longevity that is broadly accessible, sustainable, avoids pharmaceutical agents and has a range of solutions tailored for various needs and users ranging from health practitioners, through care homes to finally end users (e.g. people with sleep problems and their family members). In contrast with other existing online platforms that serve similar purposes, ISEP would target the older population and would not anchor to one type of intervention (e.g. CBTi), which has limited efficacy in older people, but build on the combinations of cutting edge innovative approaches such as the modulation of gut health, brain electric activity in sleep, as well as psychological/behaviour approaches (e.g. CBTi, mindfulness). We believe that the future of health technology lies with personalised interventions that predict efficacious intervention based on individual features, reliably monitor physiological changes and provide intervention adjustment in real-time or nearly real-time. For this to happen the quality of monitoring/data acquisition, data analysis, feature extraction and the range of interventions all need progress. Our proposal will address some of these aspects.Based on the feasibility and effect size results from the current study we plan to pursue further research to improve the technology including other dietary supplements and non-pharmaceutical methods to improve sleep with similar or better features, optimise the dosage, timing and length of administration and reliably track impact. Finally, we aim to develop broadly accessible online applications that will provide individualised guidance on a range of interventions adjusted to individual needs and with the best predictable outcome taking into account accessibility, affordability and possible side effects. This tool will not only help both the primary and secondary health care professionals but the everyday end user as well. Finally, by improving sleep our proposed approach could be employed as a preventative treatment strategy and prospectively lower economic and non-economic costs of treating and caring for individuals with dementia. Prevention is key for improving the quality of life in later stages of life and sleep and diets are two important contributors in this strategy.

我们的最终愿景是开发一个智能睡眠增强平台（ISEP），最终目标是促进健康长寿，该平台广泛可及，可持续，避免使用药物制剂，并具有一系列针对各种需求和用户的解决方案，从健康从业者到护理之家，最终用户（例如有睡眠问题的人及其家庭成员）。与其他现有的服务于类似目的的在线平台相比，ISEP将针对老年人，而不是锚于一种类型的干预措施（例如CBTi），这种干预措施对老年人的疗效有限，而是建立在最先进的创新方法的组合之上，例如调节肠道健康、睡眠中的脑电活动以及心理/行为方法（例如CBTi、正念）。我们相信，卫生技术的未来在于个性化干预，根据个人特征预测有效的干预，可靠地监测生理变化，并提供实时或接近实时的干预调整。要做到这一点，监测/数据采集、数据分析、特征提取和干预措施范围的质量都需要提高。我们的建议将解决其中的一些问题。基于目前研究的可行性和效应量结果，我们计划进行进一步的研究，以改进技术，包括其他膳食补充剂和非药物方法，以改善具有类似或更好功能的睡眠，优化剂量，时间和给药时间，并可靠地跟踪影响。最后，我们的目标是开发可广泛访问的在线应用程序，这些应用程序将提供针对个人需求调整的一系列干预措施的个性化指导，并在考虑到可访问性，可负担性和可能的副作用的情况下获得最佳可预测结果。该工具不仅可以帮助初级和二级卫生保健专业人员，还可以帮助日常终端用户。最后，通过改善睡眠，我们提出的方法可以用作预防性治疗策略，并有望降低治疗和护理痴呆症患者的经济和非经济成本。预防是提高生命后期生活质量的关键，睡眠和饮食是这一战略的两个重要贡献者。