The gut-sleep-brain axis: Targeting the gut microbiota and sleep quality by individualized non-pharmaceutical approaches to promote healthy ageing

肠道-睡眠-大脑轴：通过个体化非药物方法针对肠道微生物群和睡眠质量，促进健康老龄化

• 批准号: ES/W006367/1
• 负责人: Alpar Lazar
• 金额: $ 6.42万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FW006367%2F1
• 关键词: gut; sleep; brain; axis; Targeting

Our ultimate vision is to develop an intelligent sleep enhancement platform (ISEP) that would ultimately target the promotion of healthy longevity that is broadly accessible, sustainable, avoids pharmaceutical agents and has a range of solutions tailored for various needs and users ranging from health practitioners, through care homes to finally end users (e.g. people with sleep problems and their family members). In contrast with other existing online platforms that serve similar purposes, ISEP would target the older population and would not anchor to one type of intervention (e.g. CBTi), which has limited efficacy in older people, but build on the combinations of cutting edge innovative approaches such as the modulation of gut health, brain electric activity in sleep, as well as psychological/behaviour approaches (e.g. CBTi, mindfulness). We believe that the future of health technology lies with personalised interventions that predict efficacious intervention based on individual features, reliably monitor physiological changes and provide intervention adjustment in real-time or nearly real-time. For this to happen the quality of monitoring/data acquisition, data analysis, feature extraction and the range of interventions all need progress. Our proposal will address some of these aspects.Based on the feasibility and effect size results from the current study we plan to pursue further research to improve the technology including other dietary supplements and non-pharmaceutical methods to improve sleep with similar or better features, optimise the dosage, timing and length of administration and reliably track impact. Finally, we aim to develop broadly accessible online applications that will provide individualised guidance on a range of interventions adjusted to individual needs and with the best predictable outcome taking into account accessibility, affordability and possible side effects. This tool will not only help both the primary and secondary health care professionals but the everyday end user as well. Finally, by improving sleep our proposed approach could be employed as a preventative treatment strategy and prospectively lower economic and non-economic costs of treating and caring for individuals with dementia. Prevention is key for improving the quality of life in later stages of life and sleep and diets are two important contributors in this strategy.

我们的最终愿景是开发一个智能睡眠增强平台 (ISEP)，其最终目标是促进健康长寿，该平台可广泛使用、可持续、避免药物制剂，并针对从健康从业者、护理院到最终用户（例如有睡眠问题的人及其家人）的各种需求和用户量身定制一系列解决方案。与其他具有类似目的的现有在线平台相比，ISEP 将针对老年人群，不会固定于一种对老年人疗效有限的干预措施（例如 CBTi），而是建立在前沿创新方法的组合之上，例如肠道健康的调节、睡眠中的脑电活动以及心理/行为方法（例如 CBTi、正念）。我们相信，健康技术的未来在于个性化干预，根据个体特征预测有效的干预，可靠地监测生理变化，并实时或近实时地提供干预调整。为此，监测/数据采集、数据分析、特征提取和干预范围的质量都需要进步。我们的提案将解决其中的一些方面。根据当前研究的可行性和效果大小结果，我们计划进行进一步的研究以改进技术，包括其他膳食补充剂和非药物方法，以改善具有类似或更好功能的睡眠，优化剂量、给药时间和长度并可靠地跟踪影响。最后，我们的目标是开发可广泛访问的在线应用程序，该应用程序将为根据个人需求调整的一系列干预措施提供个性化指导，并考虑到可访问性、可负担性和可能的​​副作用，并提供最佳可预测的结果。该工具不仅可以帮助初级和二级卫生保健专业人员，还可以帮助日常最终用户。最后，通过改善睡眠，我们提出的方法可以用作预防性治疗策略，并有望降低治疗和护理痴呆症患者的经济和非经济成本。预防是改善生命后期生活质量的关键，睡眠和饮食是这一策略的两个重要贡献者。