DETERMINING THE ROLE OF ER STRESS INDUCED APOPTOSIS IN THYMIC NEGATIVE SELECTION

确定 ER 应激诱导的细胞凋亡在胸腺负选择中的作用

• 批准号: nhmrc : 487311
• 负责人: A/Pr Hamsa Puthalakath
• 金额: $ 37.22万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-role-er-negative-selection/101411
• 关键词: DETERMINING; ROLE; ER; STRESS; INDUCED

Apoptosis is an evolutionarily conserved mechanism for killing unwanted cells that are no longer needed, damaged, infected with pathogens or dangerous. Defects in apoptosis can cause a number of diseases. For example, abnormal survival of cells can cause cancer or autoimmune disease. Bim is a protein that induces apoptosis and act as a barrier against cancer and autoimmune diseases. This work is aimed at understanding how Bim acts as a barrier against the development of autoimmunity.

细胞凋亡是一种进化上保守的机制，用于杀死不再需要、受损、感染病原体或危险的不需要的细胞。细胞凋亡的缺陷可导致许多疾病。例如，细胞的异常存活可导致癌症或自身免疫性疾病。Bim是一种诱导细胞凋亡的蛋白质，并作为对抗癌症和自身免疫性疾病的屏障。这项工作旨在了解Bim如何作为自身免疫发展的障碍。