Cancer cachexia therapeutics

癌症恶病质疗法

• 批准号: nhmrc : GNT1117541
• 负责人: A/Pr Hamsa Puthalakath
• 金额: $ 62.67万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cancer-cachexia-therapeutics/1347039
• 关键词: Cancer; cachexia; therapeutics

We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.

我们已经发现了一种单一的肿瘤因子，它会导致癌症恶病质，这是恶性肿瘤最严重的并发症之一，目前还没有有效的治疗方法。我们已经开发出抗体，可以在临床前模型中有效地阻断这种情况，并已生产出这种抗体的人类/人源化版本。这个应用程序是为了描述这些人类抗体的特征，以便我们进行临床试验。