DHA for the Improvement of Neurodevelopmental Outcome in preterm infants: The DINO Trial

DHA 改善早产儿神经发育结果：DINO 试验

• 批准号: nhmrc : 250322
• 负责人: Dr Andrew Mcphee
• 金额: $ 42.13万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dha-improvement-neurodevelopmental-dino-trial/77296
• 关键词: DHA; Improvement; Neurodevelopmental; Outcome; preterm

The incidence of neurological problems that occur in children born prematurely is higher than for those born at term. The earlier that a baby is born, the greater chance it has of having some developmental delay and general inability to cope at school. This has implications for the child, the families and the health system. One of the many dietary factors implicated in the development of neural abilities in premature infants is an omega-3 fatty acid called DHA. This compound is present in breast milk and most preterm formulas and is found in high concentrations in the brain and retina. In the last third of pregnancy the developing baby would normally accumulate DHA at a rapid rate. So it seems reasonable to assume that a baby outside the mother, that is born premature, would also need to accumulate DHA at this same rate. The problem is that none of the milks currently given to premature infants have DHA in high enough concentration to supply this amount of DHA to the baby. For example, breast milk and preterm formulas contain only a third of the DHA required. In order to provide this amount for the premature infant, breast milk containing DHA at about 1% of the total fat is required. Fortunately the level of DHA in breast milk can be increased to this level by supplementing the mothers diet with fish or olis like tuna oil. This study hopes to show that premature babies who receive DHA in amounts similar to that supplied in the womb will develop better than babies who receive low amounts of DHA.

早产儿神经系统问题的发生率高于足月出生的儿童。婴儿出生越早，就越有可能出现发育迟缓和一般无法科普学校的情况。这对儿童、家庭和卫生系统都有影响。与早产儿神经能力发展有关的许多饮食因素之一是称为DHA的omega-3脂肪酸。这种化合物存在于母乳和大多数早产儿配方奶粉中，在大脑和视网膜中浓度很高。在怀孕的最后三分之一，发育中的婴儿通常会以快速的速度积累DHA。因此，似乎有理由假设，早产的婴儿也需要以同样的速度积累DHA。问题是，目前给早产儿喝的牛奶中没有一种含有足够高浓度的DHA，无法为婴儿提供足够的DHA。例如，母乳和早产儿配方奶粉仅含有所需DHA的三分之一。为了给早产儿提供这一量的DHA，需要含有约占总脂肪1%的DHA的母乳。幸运的是，母乳中的DHA水平可以通过补充鱼类或金枪鱼油等食物来提高。这项研究希望表明，接受与子宫内供应量相似的DHA的早产儿比接受低量DHA的婴儿发育得更好。