PURCHASE OF AN EPR/ENDOR SPECTROMETER

购买 EPR/ENDOR 光谱仪

• 批准号: 3519924
• 负责人: THOMAS G. SPIRO
• 金额: $ 12.5万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-30 至 1989-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519924
• 关键词: biomedical equipment resource; electron spin resonance spectroscopy; nuclear magnetic resonance spectroscopy

The Department of Chemistry at Princeton University will purchase an Electron Paramagnetic Resonance/Electron-Nuclear Double Resonance Spectrometer with support from the BRS Shared Instrumentation Program. The instrument is needed by members of the Chemistry and Biology Departments for NIH funded research in the following areas: 1. Protein Control of Proton and Electron Transfer 2. Molecular Probes of the Mechanism of Cytochrome P450 3. Cytoskeleton Membrane Interactions 4. Mechanistic Studies of alpha-Ketoacid Dioxygenasese 5. Stabilized Prostacyclins to Treat Vascular Diseases 6. Synthesis of Natural Anticancer Agents 7. Natural Product Synthesis 8. Metal Centers in Biology: Hemes, Iron-Sulfur and Copper Proteins 9. Hemeprotein Structure and Dynamics The proposed EPR spectrometer is needed to replace an aging spectrometer that was purchased in 1968 and is now out of date and partially non-functional. The ENDOR accessory will expand the capabilities of the user group into a new area by permitting high resolution studies of paramagnetic materials. This will be especially valuable for studies of the chemical structure and dynamics of distant nuclei and magnetically anisotropic materials. Through these research studies this instrument will be used in training the next generation of Princeton students entering biomedical fields.

普林斯顿大学化学系将 购买电子顺磁共振/电子核共振 双共振光谱仪在BRS的支持下 共享仪器计划。 需要该仪器 NIH化学和生物学部门的成员 在以下领域资助的研究： 1。质子和电子转移的蛋白质控制 2。细胞色素P450机理的分子探针 3。细胞骨架膜相互作用 4。α-酮酸二氧化基因的机械研究 5。稳定的前列环素以治疗血管疾病 6。天然抗癌药的合成 7。自然产品合成 8。生物学中的金属中心：血液，铁硫和铜 蛋白质 9。囊蛋白结构和动力学 提出的EPR光谱仪需要更换衰老 光谱仪于1968年购买，现在已经过时了 并且部分非功能。 Endor附件将扩展 通过允许，用户组的功能成为新区域 顺磁性材料的高分辨率研究。 这将是 对于化学结构的研究特别有价值 远处核和磁性各向异性材料的动力学。 通过这些研究，该工具将用于 培训下一代普林斯顿学生进入 生物医学领域。