National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)

项目主任/首席调查员(Freed，Jack，H.)： 具体目标 先进电子自旋国家生物医学资源中心的总体任务 共振光谱)有两个方面：(1)利用ESR的最新发展 提供最先进的设施使分子生物学家能够进行研究的技术 促进生物医学研究，以及(2)向科学家提供基于ESR的高级服务 在分子生物学的前沿(在其最一般的意义上)工作，长期 对整个生物医学研究界都有好处。Acert的一个特殊机会 该计划由目前正在完成的ESR光谱仪升级提供。 ACERT将推动尖端仪器和技术在一些 分子生物学家面临的最具挑战性的问题。我们将利用Acert的专业知识 人事、行政领导小组和外部科学咨询小组，以提供 为使用该设施的分子生物学家提供支持。 我们在此补充请求中的主要目标是最大限度地延长光谱仪的使用时间 Acert资源用户允许接受和处理更多请求并扩大范围 通过(1)实现光谱仪的全天候无制冷剂运行 和(2)通过安装商用高灵敏度样品来进一步增强其性能 谐振器。 OMB编号0925-0001/0002(批准的第03/2020版至2023年2月28日)续页格式页

Program Director/Principal Investigator (Freed, Jack, H.): Specific Aims The overall mission of ACERT (the National Biomedical Resource for Advanced Electron Spin Resonance Spectroscopy) is twofold: (1) to take advantage of the latest developments in ESR techniques to provide state-of-the-art facilities that enable molecular biologists to perform studies that advance biomedical research, and (2) to provide advanced ESR-based services to scientists working at the frontiers of molecular biology (taken in its most general sense), with long-term benefits to the biomedical research community as a whole. A special opportunity for the ACERT program is provided by upgrades to the ESR spectrometers, currently being completed. ACERT will promote the application of cutting-edge instrumentation and techniques to some of the most challenging questions confronting molecular biologists. We will use the expertise of ACERT personnel, the administrative leadership team, and the external scientific advisory group to provide support to molecular biologists using the facility. Our primary aim in this supplementary request is to maximize spectrometer live time available for the ACERT Resource users to enable accepting and processing more requests and to expand the range of amenable systems by (1) implementing round the clock cryogen-free operation of the spectrometer and (2) to further enhance its performance by installing commercial high-sensitivity sample resonators. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page