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MEDIUM FIELD 5/9 TESLA FT NMR SPECTROMETER

中场 5/9 特斯拉 FT 核磁共振波谱仪

基本信息

批准号：
3519943
负责人：
STEVEN J GOULD
金额：
$ 11.7万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-04-18 至 1989-04-17
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3519943
关键词：
biomedical equipment purchase biomedical equipment resource nuclear magnetic resonance spectroscopy

项目摘要

The Chemistry Department at Oregon State University requests funds from the National Institutes of Health for the purchase of a medium-field nuclear magnetic resonance (NMR) spectrometer (5.9 Tesla, 250 MHz for proton). Research projects for which this spectrometer will be used include synthetic, biosynthetic, and mechanistic organic chemistry, biophysical studies of peptides and of oligonucleotides and oligonucleotide mimics, and natural products structural determination. The individual projects describe areas of chemical research that depend on NMR spectroscopy for accurate data on molecular structure and dynamics. These projects have become increasingly hampered by the lack of an instrument with field strength intermediate between the department's Bruker AM 400 spectrometer and two 1.9 Tesla iron magnet spectrometers. The limited resolution, sensitivity, and versatility of the small spectrometers has resulted in very high - and increasing - usage of the sole super-conducting magnet instrument in the department. With the recent acquisition of new faculty, the expansion of existing research groups, and the desire of biophysicists at OSU to initiate NMR- based studies, severe scheduling problems have arisen with the AM 400 instrument. The addition of a medium-field spectrometer to the department's NMR facility will alleviate this problem and will give new impetus to the research efforts of a large number of users whose interests are centered around chemistry and its associated disciplines.

俄勒冈州州立大学的化学系要求美国国立卫生研究院的资金用于购买中场核磁共振谱仪 (5.9特斯拉，质子为250 MHz）。这些研究项目将使用光谱仪，包括合成的、生物合成的机械有机化学，肽的生物物理学研究，寡核苷酸和寡核苷酸模拟物，产品结构确定。个别项目描述依赖于NMR的化学研究领域光谱学用于分子结构的精确数据，动力学这些项目越来越受到阻碍，缺乏一种场强介于该部门的布鲁克AM 400光谱仪和两个 1.9特斯拉铁磁光谱仪。有限的分辨率，灵敏度和小型光谱仪的多功能性，在非常高的-和越来越多的-使用唯一的超导磁性仪器在该部门。随着近期获取新的教师，扩大现有的研究集团，并在俄勒冈州立大学的生物药理学家的愿望，以启动核磁共振- 基于研究，严重的调度问题已经出现， AM 400仪器。增加了一个中场分光计到该部门的核磁共振设施将缓解这个问题，将为大量的研究工作提供新的动力，用户的兴趣集中在化学及其相关学科。