MEDIUM FIELD 5/9 TESLA FT NMR SPECTROMETER

俄勒冈州立大学化学系要求 来自国家卫生研究院的资金，用于购买 中场核磁共振谱仪 (5.9特斯拉，250兆赫质子)。这个项目的研究项目 将使用的分光计包括合成、生物合成和 机械有机化学、多肽和生物物理研究 寡核苷酸和寡核苷酸模拟物，以及天然的 产品结构确定。个别项目 描述依赖于核磁共振的化学研究领域 光谱学，获得关于分子结构和 动力学。这些项目越来越多地受到 缺少具有中场强的仪器 在该部门的布鲁克AM 400光谱仪和两台 1.9特斯拉铁磁光谱仪。有限的决议， 小型光谱仪的灵敏度和多功能性导致了 在唯一超导的使用率非常高且不断增加的情况下 磁铁仪器在该部门。随着最近的 获得新的教员，扩大现有研究 以及俄亥俄州立大学生物物理学家希望启动核磁共振- 基于研究，严重的调度问题已经出现在 AM 400仪器。增加一台中场光谱仪 该部门的核磁共振设施将缓解这个问题， 将为一大批的研究工作注入新的动力 用户的兴趣集中在化学及其 相关联的学科。

The Chemistry Department at Oregon State University requests funds from the National Institutes of Health for the purchase of a medium-field nuclear magnetic resonance (NMR) spectrometer (5.9 Tesla, 250 MHz for proton). Research projects for which this spectrometer will be used include synthetic, biosynthetic, and mechanistic organic chemistry, biophysical studies of peptides and of oligonucleotides and oligonucleotide mimics, and natural products structural determination. The individual projects describe areas of chemical research that depend on NMR spectroscopy for accurate data on molecular structure and dynamics. These projects have become increasingly hampered by the lack of an instrument with field strength intermediate between the department's Bruker AM 400 spectrometer and two 1.9 Tesla iron magnet spectrometers. The limited resolution, sensitivity, and versatility of the small spectrometers has resulted in very high - and increasing - usage of the sole super-conducting magnet instrument in the department. With the recent acquisition of new faculty, the expansion of existing research groups, and the desire of biophysicists at OSU to initiate NMR- based studies, severe scheduling problems have arisen with the AM 400 instrument. The addition of a medium-field spectrometer to the department's NMR facility will alleviate this problem and will give new impetus to the research efforts of a large number of users whose interests are centered around chemistry and its associated disciplines.