AGE-RELATED CHANGES IN THE VESTIBULAR LABYRINTH

前庭迷路与年龄相关的变化

• 批准号: 3115400
• 负责人: JANIE C PARK
• 金额: $ 6.1万
• 依托单位: FLORIDA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-05-01 至 1989-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3115400
• 关键词: aging; animal age group; cell death; cell type; cellular pathology; disease /disorder model; ear hair cell; electron microscopy; genotype; hearing disorders; histology; image processing; labyrinth; microscopy; neural transmission; organelles; ototoxin; sign /symptom; synapses; vestibular apparatus; vestibular pathway

Equilibular disturbances are common in the elderly (1) and this decline in function probably indicates cellular deterioration. However, in humans it is difficult to separate the cellular changes that are age-related from those brought about by a lifetime of disease and antibiotic therapy. The establishment of a convenient animal model is important for many experiments relating balance organs and age. The aim of the proposed research is to describe the cellular changes occurring in the vestibular organs of the inner ears of C57BL/6 mice as a result of aging. Although the mouse is commonly used as a model for other types of inner ear research (2-6), no quantitative ultrastructural information is available on the aging mouse vestibular organs nor on genotype-specific progressive degeneration. The saccule, utricle, and semicircular canal ampullae of six age groups from weanling to very old will be compared to determine the temporal sequence oc cytological aging in this mouse strain. Standard morphometric and stereological techniques at the light and electron microscopic level will be used to describe the cytology of the sensory epithelium. Variation and significant changes will be analyzed at the following four levels: within an organ, among different organs in the same animal, among animals within an age group, and among the six age groups. A video image analysis system will be employed for semi-automated data collection and analysis.

平衡紊乱在老年人中很常见(1)，这种衰退在老年人中很常见

项目成果

The developing and senescent inner ear: selected topics and models.

发育中和衰老的内耳：选定的主题和模型。

• 发表时间: 1988
• 期刊: Critical reviews in neurobiology
• 作者: Cohen,GM;Park,JC
• 通讯作者: Park,JC

Volume fraction and ultrastructure of age pigment in the saccular epithelium of old mice.

老年小鼠囊状上皮中老年色素的体积分数和超微结构。

• DOI: 10.1016/0378-5955(89)90038-5
• 发表时间: 1989
• 期刊: Hearing research
• 影响因子: 2.8
• 作者: Hubel,SB;Park,JC
• 通讯作者: Park,JC

Cholinesterase activity in vestibular organs of young and old mice.

年轻和年老小鼠前庭器官中的胆碱酯酶活性。

• DOI: 10.1016/0378-5955(92)90128-a
• 发表时间: 1992
• 期刊: Hearing research
• 影响因子: 2.8
• 作者: McLamb,WT;Park,JC
• 通讯作者: Park,JC

Persistence of synaptic bodies in saccular hair cells of senescent mice.

衰老小鼠囊状毛细胞中突触体的持续存在。

• DOI: 10.3109/00016488709107318
• 发表时间: 1987
• 期刊: Acta oto-laryngologica
• 影响因子: 1.4
• 作者: Woods,AD;Park,JC
• 通讯作者: Park,JC