NATIONAL VIBRATING PROBE FACILITY

国家振动探头设施

• 批准号: 3103898
• 负责人: LIONEL F JAFFE
• 金额: $ 32.72万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103898
• 关键词: biomedical automation; biomedical equipment resource; electrical potential; ion transport; microelectrodes; single cell analysis

We propose to continue and expand the National Vibrating Probe Facility. This expansion should bring the facility up to full operating capacity and allow us to best serve users throughout the country (as well as abroad). It should also allow us to develop a series of ion-specific vibrating probes and an aerial vibrating probe; to extend our measurements of endogenous ionic currents to certain plasmalemma-free preparations; to continue our collaborative exploration of possible currents through the tips of growing nerves as well as the vegetal poles of various embryos; and to continue training new users and disseminating news of our findings and capacities. The user projects should continue to focus on a wide variety of growing and developing systems as well as mature, functioning epithelia. Moreover, they should include ones of medical as well as basic biological interest, particularly in the general area of wound healing and regeneration.

我们建议继续和扩大国家振动探针设施。 这一扩建将使该设施达到全部作业能力， 使我们能够更好地为全国（以及国外）的用户服务。 它还可以让我们开发一系列离子特异性振动 探针和一个空中振动探针;扩大我们的测量 某些无质膜制剂的内源性离子电流; 继续我们的合作探索可能的电流通过 生长神经的尖端以及各种胚胎的植物极;以及 继续培训新用户，传播我们的研究结果， 能力。 用户项目应继续关注各种不断增长的和 发育系统以及成熟的功能性上皮细胞。 此外，委员会认为， 它们应包括具有医学和基本生物学意义的内容， 特别是在伤口愈合和再生的一般领域。