BEHAVIORAL CORRELATES OF ENDOCRINE DISORDERS IN CHILDREN

儿童内分泌失调的行为相关性

• 批准号: 3942098
• 负责人: R P KLEIN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942098
• 关键词: Prader Willi syndrome; Turner's syndrome; adolescence (12-20); body physical characteristic; child behavior; child behavior disorders; child physical development; disease /disorder proneness /risk; endocrine disorder; gonadotropins; hormone regulation /control mechanism; human puberty; human subject; interview; middle childhood (6-11); precocious puberty; psychobiology; psychological adaptation; sex hormones; social adjustment; social behavior; somatotropin

This project encompasses a series of studies examining the behavioral correlates of endocrine disorders in young patients, including children with precocious puberty, Turner's syndrome, and growth hormone deficiency. A first objective was to determine whether these children are at risk for problems in psychosocial adjustment. In a sample of children with precocious puberty, we reported that these children do, in fact, show an above-normal incidence of a variety of adjustment problems. A current objective is to ascertain the factor(s) responsible for this finding. Analyses during the past fiscal year have focused on the combined influence of age of onset, duration of symptoms before treatment was begun, and pretreatment medical status as indicated by bone age, relative height, pubic hair stage and the levels of gonadotropins and sex steroids. In general these factors had a synergistic effect, i.e., their influence was stronger when taking into account the other factors than when looking at their influence individually. This project has been terminated.

该项目包括一系列研究，考察 年轻患者内分泌紊乱的行为相关性， 包括性早熟、特纳综合征、 和生长激素缺乏症。第一个目标是 确定这些儿童是否有患上问题的风险 心理社会适应。在早熟儿童的样本中 青春期，我们报告说，事实上，这些孩子确实表现出 超常发生的各种调整问题。一个 目前的目标是确定造成这种情况的因素(S) 找到了。上一财年的分析重点是 起病年龄、发病前症状持续时间的综合影响 治疗开始了，治疗前的医疗状况为 通过骨龄、相对高度、阴毛阶段和 促性腺激素和性激素水平。总的来说，这些因素 具有协同效应，即当他们的影响力更强时 考虑到其他因素，而不是在查看其 个人影响。这个项目已经终止了。