BEHAVIORAL CORRELATES OF ENDOCRINE DISORDERS IN CHILDREN

这个项目包含了一系列研究，考察了 内分泌紊乱的相关性，包括性早熟儿童 青春期、特纳综合征和生长激素缺乏症。第一次 目的是确定这些儿童是否有出现问题的风险 在心理社会适应方面。在早熟儿童的样本中 青春期，我们报告说，事实上，这些孩子确实表现出了超乎正常的 各种调整问题的发生。当前的目标是 查明导致这一发现的因素(S)。分析过程中 上一财年的重点是3个问题：(1)更仔细地审查 先前报道的年龄和行为问题之间的关系被揭示 直到8岁才接受治疗的儿童非常 高风险(85%)的临床水平的行为问题。我们目前正在 确定这一群体的哪些特征可能导致 这一发现。(2)举报行为治疗无效。 问题，尽管治疗在减少性类固醇方面有效 和促性腺激素水平。这表明，我们面临的调整困难 在这个样本中看到的不是荷尔蒙作用的直接结果。(3) 特发性病例与Tanner分期匹配病例的比较 来自正在进行的正常青春期NIMH研究的数据显示了几个不同之处 在行为调整方面。在几个地区，先驱们表现出了 与对照案例相比，调整困难更大，特别是 关于多动症。(4)与以前的研究相比，我们 在5至8岁的女孩样本中没有发现言语智商优越的证据 患有特发性青春期早熟。

This project encompasses a series of studies examining the behavioral correlated of endocrine disorders, including children with precocious puberty, Turner's syndrome and growth hormone deficiency. A first objective was to determine whether these children are at risk for problems in psychosocial adjustment. In a sample of children with precocious puberty, we reported that these children do, in fact, show an above-normal incidence of a variety of adjustment problems. A current objective is to ascertain the factor(s) responsible for this finding. Analyses during the past fiscal year have focused on 3 issues: (1) Closer examination of the previously reported relation between age and behavior problems revealed that children who did not receive treatment until 8 years old were at very high risk (85%) for clinical levels of behavior problems. We are currently determining what characteristics of this group could be responsible for this finding. (2) There was no effect of treatment for reported behavior problems even though the treatment was effective in reducing sex steroid and gonadotropin levels. This suggests that the adjustment difficulties we have seen in this sample are not the direct result of hormonal action. (3) Comparison between our idiopathic cases and cases matched on Tanner stage data from an ongoin NIMH study of normal puberty showed several differences in behavioral adjustment. In several areas the probands showed evidence of greater adjustment difficulties than did the control cases, particularly with regard to hyperactivity. (4) In contrast to previous research, we found no evidence of verbal IQ superiority in a sample of girls aged 5 to 8 with idiopathic precocious puberty.