BEHAVIORAL CORRELATES OF ENDOCRINE DISORDERS IN CHILDREN

儿童内分泌失调的行为相关性

• 批准号: 3965832
• 负责人: R P KLEIN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965832
• 关键词: Prader Willi syndrome; Turner's syndrome; adolescence (12-20); body physical characteristic; child behavior; child behavior disorders; child physical development; disease /disorder proneness /risk; endocrine disorder; hormone regulation /control mechanism; human puberty; human subject; interview; middle childhood (6-11); precocious puberty; psychobiology; psychological adaptation; sex hormones; social behavior; somatotropin

This project encompasses a series of studies examining the behavioral correlates of endocrine disorders in young patients, including children with precocious puberty, Turner's syndrome, and growth hormone deficiency. A first objective was to determine whether these children are at risk for problems in psychosocial adjustment. In a sample of children with precocious puberty, we reported that these children do, in fact, show an above-normal incidence of a variety of adjustment problems. A current objective is to ascertain the factor(s) responsible for this finding. Analyses during the past fiscal year have focused on the combined influence of age of onset, duration of symptoms before treatment was begun, and pretreatment medical status as indicated by bone age, relative height, pubic hair stage and the levels of gonadotropins and sex steroids. In general these factors had a synergistic effect, i.e., their influence was stronger when taking into account the other factors than when looking at their influence individually.

该项目包括一系列研究，检查行为 年轻患者（包括儿童）内分泌失调的相关性 患有性早熟、特纳综合症和生长激素缺乏症。 第一个目标是确定这些儿童是否面临以下风险： 心理社会适应问题。 在儿童样本中 性早熟，我们报告说，这些孩子实际上确实表现出 各种调整问题的发生率高于正常水平。 电流 目的是确定造成这一结果的因素。 上一财年的分析重点关注综合影响 发病年龄、治疗开始前症状持续时间，以及 治疗前的医疗状况，如骨龄、相对身高、 阴毛阶段以及促性腺激素和性类固醇的水平。 在 一般来说，这些因素具有协同效应，即它们的影响是 考虑其他因素时的效果比只考虑其他因素时的效果更强 他们各自的影响力。