CORONARY CIRCULATORY CONTROL AND PATHOPHYSIOLOGY

这是一个已建立的计划的更新申请- 项目开始与心肺主题，但现在 完全专注于冠状动脉循环控制， 病理生理学 目前的项目结构包括四个 研究领域和四个支持核心单位。 项目我 提出了控制冠状动脉压力的机制- 流动行为，使用实验设计，旨在处理 潜在的混淆问题，从而解决当前 争议点。 项目二继续进行研究， 冠状动脉输入阻抗，延长观察期 完整的心动周期，并解决收缩-舒张 流动相互作用，心肌内电容的影响， 动脉电容的分布。 项目 第三章讨论了调节自身调节反应的因素， 急性和慢性局部冠状动脉压力降低 在有意识的动物中，强调流动之间的相互作用， 功能和压力接近自动调节下限， 传统的稳态压力-流量关系。 项目四 反映了目前临床和实验的强烈兴趣 冠状动脉再灌注 早期研究心肌损伤和 最近在再灌注期间的动物和人类研究表明， 肌红蛋白是检测再灌注的有用试剂 非侵入性地并评估几个相关的后果。 总体方案-项目战略继续强调 研究人员之间的科学互动， 研究兴趣和努力跨越学科界限， 他们的活动是通过合作奋进促进的， 共享核心实验室设施。 预期结果是 一个创新、稳定的方案， 基础和应用冠状动脉研究

This is a renewal application from an established Program- Project which began with a cardiopulmonary theme but now focuses entirely on coronary circulatory control and pathophysiology. Current program structure includes four research areas and four supporting core units. Project I addresses mechanisms postulated to control coronary pressure- flow behavior, using experimental designs intended to deal with potentially confounding issues and thereby resolve currently controversial points. Project II continues ongoing studies of coronary input impedance, extending observations during diastole to the full cardiac cycle and also addressing systolic-diastolic flow interactions, effects of intramyocardial capacitance and the distribution of arterial components of capacitance. Project III addresses factors modulating autoregulatory responses to acute and chronic reductions in regional coronary artery pressure in conscious animals, emphasizing interactions among flow, function and pressure near the lower auto-regulatory limit of the traditional steady-state pressure-flow relationship. Project IV reflects the currently intense clinical and experimental interest in coronary reperfusion. Earlier studies of myocardial injury and recent animal and human studies during reperfusion indicate that myoglobin is a useful agent for detecting reperfusion noninvasively and evaluating several pertinent consequences. Overall Program-Project strategy continues to emphasizes scientific interaction among investigators whose personal research interests and efforts cross interdisciplinary lines, and whose activities are facilitated by collaborative endeavor in shared core laboratory facilities. The intend result is an innovative, stable program having a synergistic effect on both basic and applied coronary research.