CORONARY CIRCULATORY CONTROL AND PATHOPHYSIOLOGY

这是一个已建立的计划的续订申请- 从心肺主题开始的项目，但现在 完全专注于冠状动脉循环控制和 病理生理学。目前的程序结构包括四个 研究区域和四个支持核心单位。项目一 阐述了控制冠脉压力的机制- 流动行为，使用旨在处理以下问题的实验设计 潜在的混淆问题，从而解决当前 有争议的几点。项目II继续进行中的研究 冠脉输入阻抗，舒张期延长观察 到整个心脏周期，也解决了收缩-舒张期 流动相互作用，心肌内电容和 动脉电容各分量的分布。项目 III阐述了调节自动调节反应的因素 局部冠状动脉压力的急性和慢性降低 在有意识的动物中，强调流动之间的相互作用， 接近自动调节下限的功能和压力 传统的稳态压力-流量关系。项目IV 反映了目前临床和实验的强烈兴趣 在冠状动脉再灌流中。早期对心肌损伤的研究和 最近的动物和人类研究表明，在再灌流期间 肌红蛋白是检测再灌流的有用试剂 非侵入性，并评估几个相关的后果。 总体规划-项目战略继续强调 调查人员之间的科学互动，其个人 研究兴趣和努力跨越跨学科界限，以及 其活动是通过以下合作努力促进的 共享核心实验室设施。预期结果是一个 创新、稳定的计划对两者都有协同效应 基础和应用冠状动脉研究。

This is a renewal application from an established Program- Project which began with a cardiopulmonary theme but now focuses entirely on coronary circulatory control and pathophysiology. Current program structure includes four research areas and four supporting core units. Project I addresses mechanisms postulated to control coronary pressure- flow behavior, using experimental designs intended to deal with potentially confounding issues and thereby resolve currently controversial points. Project II continues ongoing studies of coronary input impedance, extending observations during diastole to the full cardiac cycle and also addressing systolic-diastolic flow interactions, effects of intramyocardial capacitance and the distribution of arterial components of capacitance. Project III addresses factors modulating autoregulatory responses to acute and chronic reductions in regional coronary artery pressure in conscious animals, emphasizing interactions among flow, function and pressure near the lower auto-regulatory limit of the traditional steady-state pressure-flow relationship. Project IV reflects the currently intense clinical and experimental interest in coronary reperfusion. Earlier studies of myocardial injury and recent animal and human studies during reperfusion indicate that myoglobin is a useful agent for detecting reperfusion noninvasively and evaluating several pertinent consequences. Overall Program-Project strategy continues to emphasizes scientific interaction among investigators whose personal research interests and efforts cross interdisciplinary lines, and whose activities are facilitated by collaborative endeavor in shared core laboratory facilities. The intend result is an innovative, stable program having a synergistic effect on both basic and applied coronary research.