CORONARY CIRCULATORY CONTROL, FUNCTION & TISSUE EXCHANGE

冠状动脉循环控制、功能

• 批准号: 3097524
• 负责人: FRANCIS J KLOCKE
• 金额: $ 54.95万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3097524
• 关键词: arrhythmia; coronary disorder; heart circulation

This is a program-project which encompasses a broadly based confederation of interrelated cardiopulmonary research projects dealing with impaired blood and tissue oxygenation and the pathophysiological consequences thereof. Scientific emphasis is focused on pulmonary gas exchange and myocardial oxygen delivery, with the myocardial effort including a multifaceted assault on the difficult barriers to our understanding and treatment of coronary artery disease. Sub-programs include: "Coronary Circulation in Normal and Abnormal States" focusing on the evaluation of heterogeneous myocardial perfusion, including assessment of regional perfusion; "Kinetics of Gas Exchange in the Lung and Tissues" investigating the mechanism an kinetics of the Haldane effect, as well a studying the speed of the Bohr shift in the intact erythrocyte; "Factors Influencing Distribution of Ventilation", having as its primary goal the determination of the distribution of ventilation-perfusion ratios from steady-state measurements of intrapulmonary elimination of several inert gas tracers; and "Comparative Electrophysiological Behavior of Atrial Specialized Fibers and Purkinje Fiber; Electrogenic Basis for Positive Chronotropic Effects of Cardiac Glycosides".

这是一个方案项目，包括一个基础广泛的联合会， 相关的心肺研究项目处理受损的血液和 组织氧合及其病理生理学后果。 科学 重点集中在肺气体交换和心肌氧输送， 随着心肌的努力，包括对困难的多方面攻击， 对我们理解和治疗冠状动脉疾病的障碍。 子程序包括：“冠状动脉循环正常和异常状态” 侧重于评价异质性心肌灌注，包括 局部灌注的评估;“肺和肺内气体交换的动力学” 组织”调查机制和动力学的Halcantine效应，以及 a研究完整红细胞中玻尔位移的速度;“因素 影响通风分布”，其主要目标是 确定通气-灌注比的分布， 几种惰性气体肺内消除稳态测量 示踪剂;和“心房特化的比较电生理行为 纤维和浦肯野纤维;正性变时效应的电基础 心脏糖苷类化合物”。