CORONARY CIRCULATORY CONTROL, FUNCTION & TISSUE EXCHANGE

这是一个计划项目，它包括一个基础广泛的 相关的心肺研究项目处理受损的血液和 组织氧合及其病理生理学后果。科学 重点放在肺气体交换和心肌氧输送上， 与心肌努力包括对困难的多方面攻击 阻碍了我们对冠心病的理解和治疗。 子计划包括：“正常和异常状态下的冠脉循环” 重点评价异质性心肌灌注，包括 区域血流灌注的评估；肺和肺内气体交换的动力学 组织研究霍尔丹效应的机制和动力学 关于完整红细胞玻尔移位速度的研究 《影响通风分布》，其首要目标是 空气通透性-灌注率分布的测定 几种惰性气体肺内排泄的稳态测量 示踪剂；和“特化心房的比较电生理行为 纤维和蒲肯野纤维.正变时性效应的电基础 心脏糖苷的作用“。

This is a program-project which encompasses a broadly based confederation of interrelated cardiopulmonary research projects dealing with impaired blood and tissue oxygenation and the pathophysiological consequences thereof. Scientific emphasis is focused on pulmonary gas exchange and myocardial oxygen delivery, with the myocardial effort including a multifaceted assault on the difficult barriers to our understanding and treatment of coronary artery disease. Sub-programs include: "Coronary Circulation in Normal and Abnormal States" focusing on the evaluation of heterogeneous myocardial perfusion, including assessment of regional perfusion; "Kinetics of Gas Exchange in the Lung and Tissues" investigating the mechanism an kinetics of the Haldane effect, as well a studying the speed of the Bohr shift in the intact erythrocyte; "Factors Influencing Distribution of Ventilation", having as its primary goal the determination of the distribution of ventilation-perfusion ratios from steady-state measurements of intrapulmonary elimination of several inert gas tracers; and "Comparative Electrophysiological Behavior of Atrial Specialized Fibers and Purkinje Fiber; Electrogenic Basis for Positive Chronotropic Effects of Cardiac Glycosides".