MyoSock - Measuring muscle health in healthy ageing

MyoSock - 测量健康老龄化过程中的肌肉健康状况

• 批准号: ES/Y001419/1
• 负责人: Annette Pantall
• 金额: $ 12.84万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FY001419%2F1
• 关键词: MyoSock; Measuring; muscle; health; healthy

The ISCF Healthy Ageing Follow on Fund 2023 is part of the Healthy Ageing Catalyst Award programme, funded by the UKRI Healthy Ageing Challenge and in collaboration with the US National Academy of Medicine's (NAM) Healthy Longevity Global Grand Challenge. With Zinc's programme of support, the Follow on Funding will be used to build upon previous Healthy Ageing Catalyst Award funding, with the aim of commercialising research in a wearable device to measure age-related changes in muscle health. Muscle wasting affects 2% of the population - about 156 million people world-wide. A decrease in muscle tissue reduces the force necessary to perform movements such as walking. This may result in decreased mobility which impacts quality of life and increases falls risk. As the population ages, sarcopenia (age-related muscle wasting) will affect a projected 18-32 million Europeans by 2045. Health care costs directly associated with muscle weakness and sarcopenia were estimated to be £2.5 billion in the UK in 2016. Sarcopenia is a progressive muscle disease and loss of muscle starts as early as the fourth decade of life. Skeletal muscle, the largest organ in the body, is involved with many other functions, other than movement, through the release of a type of hormone called myokine. These myokines have an effect on, for example, cognitive function, obesity, type 2 diabetes and cardiovascular disease. Muscle wasting is present in a diverse range of illnesses and conditions such as diabetes, cancer, liver disease, alcoholism and prolonged bed rest. Assessing the health of the muscular system and developing appropriate interventions is therefore essential for advancing healthy ageing, longevity, and quality of life. However, there is no reliable non-invasive, low-cost method of measuring muscle health. Muscle activity can be recorded by measuring the small electrical potentials transmitted from muscles to the skin, known as electromyography (EMG). Muscle volume can be measured using ultrasound or magnetic resonance imaging. However, muscle health is not just a measure of the amount of electrical activity within a muscle, or how large the muscle is, but also how activity and volume are linked to functional performance. There is therefore an urgent need to develop a device that can measure muscle health using multiple types of sensors. This project aims to develop a low cost, simple to use smart sock with embedded sensors and associated software for measuring muscle health.

ISCF健康老龄化后续基金2023是健康老龄化催化剂奖计划的一部分，由UKRI健康老龄化挑战资助，并与美国国家医学院（NAM）健康长寿全球大挑战合作。在Zinc的支持计划下，后续资金将用于建立以前的健康老龄化催化剂奖资金，目的是将可穿戴设备的研究商业化，以测量与年龄相关的肌肉健康变化。肌肉萎缩影响了2%的人口-全世界约1.56亿人。肌肉组织的减少减少了进行诸如行走等运动所需的力量。这可能导致活动性降低，从而影响生活质量并增加福尔斯风险。随着人口老龄化，到2045年，预计将有1800万至3200万欧洲人受到肌肉减少症（与年龄相关的肌肉萎缩）的影响。2016年，英国与肌肉无力和肌肉减少症直接相关的医疗保健费用估计为25亿英镑。肌肉减少症是一种进行性肌肉疾病，肌肉损失早在生命的第四个十年开始。骨骼肌是人体最大的器官，通过释放一种称为肌因子的激素，除了运动之外，还涉及许多其他功能。这些肌因子对例如认知功能、肥胖、2型糖尿病和心血管疾病有影响。肌肉萎缩存在于各种疾病和状况中，如糖尿病，癌症，肝病，酗酒和长期卧床休息。因此，评估肌肉系统的健康状况并制定适当的干预措施对于促进健康老龄化、长寿和生活质量至关重要。然而，没有可靠的非侵入性，低成本的方法来测量肌肉健康。肌肉活动可以通过测量从肌肉传输到皮肤的微小电位来记录，称为肌电图（EMG）。肌肉体积可以使用超声或磁共振成像来测量。然而，肌肉健康不仅仅是衡量肌肉内的电活动量，或者肌肉有多大，还包括活动和体积如何与功能表现联系起来。因此，迫切需要开发一种可以使用多种类型的传感器来测量肌肉健康的设备。该项目旨在开发一种低成本，简单易用的智能袜子，内置传感器和相关软件，用于测量肌肉健康。