OBSERVATIONS ON CEREBRAL ISCHEMIA AT INJURY THRESHOLD LEVELS

损伤阈值水平脑缺血的观察

• 批准号: 3945334
• 负责人: M SEIDA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3945334
• 关键词: brain cell; brain edema; brain injury; cell death; cerebral artery; cerebral ischemia /hypoxia; cerebrovascular occlusions; neurons; nonsurgical revascularization

Studies on mechanisms, associated with survival of the neurons subjected to ischemia, have important clinical implications, since elucidation of the nature of such mechanisms may ameliorate or prevent brain tissue damage following cerebral ischemia insults. In experimental research, the degree of ischemic injury which allows recovery of affected neurons is called "penumbra", i.e. resembling a twilight zone around solar eclipse. In our studies, we produced conditions of penumbra by subjecting cats to 20 minute occlusion of the middle cerebral artery (MCA) and studying various parameters of ischemic injury up to 2 weeks after the insult. Our studies demonstrated that although the animals showed significant and widespread changes up to 3 days after recirculation, there was either complete or partial recovery with regard to edema and neuronal damage, when animals were examined 2 weeks after MCA occlusion. Our investigations resulted thus in establishing an experimental model where pathomechanisms associated with reversible ischemic damage could be analyzed and, potentially, manipulated.

与神经元存活相关的机制研究 具有重要的临床意义，因为 阐明这种机制的性质可以改善或 防止脑缺血损伤后的脑组织损伤。 在实验研究中，缺血损伤的程度， 允许受影响的神经元恢复被称为“半影”，即 类似于日食周围的微光区。 在我们的研究中， 通过将猫置于20分钟的 大脑中动脉（MCA）闭塞和研究 缺血性损伤后2周的各种参数 侮辱。 我们的研究表明，尽管动物 显示了显著和广泛的变化，长达3天后， 再循环，有完全或部分恢复， 关于水肿和神经元损伤，当动物 MCA闭塞后2周检查。 我们的调查 从而建立了一个实验模型， 可逆性缺血损伤的病理机制 可以被分析和操纵