OBSERVATIONS ON CEREBRAL ISCHEMIA AT INJURY THRESHOLD LEVELS

与神经元存活相关的机制研究 缺血，具有重要的临床意义，因为 阐明这种机制的性质可能会改善或 预防脑缺血损伤后的脑组织损伤。 在实验研究中，脑缺血损伤的程度 允许受影响神经元的恢复被称为“半影区”，即 类似于日食周围的黄昏地带。在我们的研究中， 我们给猫20分钟的时间来创造半暗带的条件 大脑中动脉闭塞及其相关因素的研究 损伤后2周内的缺血损伤参数。我们的 研究表明，尽管这些动物表现出显著的 并在再循环后3天出现广泛的变化 完全或部分恢复关于水肿症和 大脑中动脉后2周对动物进行神经元损伤检查 遮挡。我们的调查结果是建立了一个 发病机制与可逆性相关的实验模型 可以对缺血损伤进行分析，并有可能进行操纵。

Studies on mechanisms, associated with survival of the neurons subjected to ischemia, have important clinical implications, since elucidation of the nature of such mechanisms may ameliorate or prevent brain tissue damage following cerebral ischemic insults. In experimental research, the degree of ischemic injury which allows recovery of affected neurons is called "penumbra", i.e. resembling a twilight zone around solar eclipse. In our studies, we produced conditions of penumbra by subjecting cats to 20 minute occlusion of the middle cerebral artery (MCA) and studying various parameters of ischemic injury up to 2 weeks after the insult. Our studies demonstrated that although the animals showed significant and widespread changes up to 3 days after recirculation, there was either complete or partial recovery with regard to edema and neuronal damage, when animals were examined 2 weeks after MCA occlusion. Our investigations resulted thus in establishing an experimental model where pathomechanisms associated with reversible ischemic damage could be analyzed and, potentially, manipulated.