OBSERVATIONS ON CEREBRAL ISCHEMIA AT INJURY THRESHOLD LEVELS

与神经元存活相关的机制研究 具有重要的临床意义，因为 阐明这种机制的性质可以改善或 预防脑缺血损伤后的脑组织损伤。 在实验研究中，缺血损伤的程度， 允许受影响的神经元恢复被称为“半影”，即 类似于日食周围的微光区。 在我们的研究中， 我们通过让猫接受20分钟的 大脑中动脉（MCA）闭塞，并研究各种 损伤后2周内的缺血性损伤参数。 我们 研究表明，尽管动物表现出显著的 和广泛的变化，长达3天后，再循环，有 水肿完全或部分恢复， MCA后2周检查动物时，神经元损伤 闭塞 因此，我们的调查结果建立了一个 实验模型，其中与可逆性 可以分析和潜在地操纵缺血性损伤。

Studies on mechanisms, associated with survival of the neurons subjected to ischemia, have important clinical implications, since elucidation of the nature of such mechanisms may ameliorate or prevent brain tissue damage following cerebral ischemic insults. In experimental research, the degree of ischemic injury which allows recovery of affected neurons is called "penumbra", i.e. resembling a twilight zone around solar eclipse. In our studies, we produced conditions of penumbra by subjecting cats to 20 minute occlusion of the middle cerebral artery (MCA) and studying various parameters of ischemic injury up to 2 weeks after the insult. Our studies demonstrated that although the animals showed significant and widespread changes up to 3 days after recirculation, there was either complete or partial recovery with regard to edema and neuronal damage, when animals were examined 2 weeks after MCA occlusion. Our investigations resulted thus in establishing an experimental model where pathomechanisms associated with reversible ischemic damage could be analyzed and, potentially, manipulated.