EFFECT OF AMINOPHYLLINE ON POST-ISCHEMIC EDEMA AND BRAIN INJURY

氨茶碱对缺血后水肿和脑损伤的影响

• 批准号: 3922624
• 负责人: M SEIDA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922624
• 关键词: aminophylline; blood brain barrier; brain edema; brain injury; cardiovascular disorder chemotherapy; cardiovascular pharmacology; cats; cerebral artery; cerebral ischemia /hypoxia; cerebrovascular occlusions; dosage; drug administration rate /duration; histopathology; nonsurgical revascularization; radiotracer

Effect of aminophylline on post-ischemic edema and brain injury was studied in cats subjected to the middle cerebral artery (MCA) occlusion for 1 hour. Administration of aminophylline 22.8 mg/kg infused for 15 minutes at the time of release of MCA occlusion resulted in suppression of reactive hyperemia and proved to have an unequivocal beneficial effect on development of post-ischemic edema and brain injury. The animals with aminophylline showed no breakdown of the blood-brain barrier to protein tracers and showed no significant edema in the ischemic regions, when sacrificed 3 hours after release of MCA occlusion. Also, cats with aminophylline treatment revealed significantly milder ischemic injury when studied histologically at 3 and 14 day periods after recirculation. Our studies thus demonstrate a marked beneficial effect of aminophylline with a potential to be considered for treatment of patients in certain clinical conditions.

氨茶碱对缺血后水肿和脑损伤的作用 在接受大脑中动脉 (MCA) 治疗的猫身上进行了研究 闭塞1小时。 给予氨茶碱 22.8 mg/kg MCA 闭塞解除时输注 15 分钟 导致反应性充血的抑制，并被证明具有 对缺血后的发育具有明确的有益作用 水肿和脑损伤。 服用氨茶碱的动物没有表现出 蛋白质示踪剂破坏血脑屏障并显示 处死时缺血区无明显水肿 3 MCA 闭塞解除后数小时。 此外，猫还带有 氨茶碱治疗显示缺血明显减轻 损伤后 3 天和 14 天进行组织学研究 再循环。 因此，我们的研究表明， 氨茶碱有可能被考虑用于治疗 处于某些临床状况的患者。