Proof of concept study of combined allergen immunotherapy and antibiotics for the treatment of chronic atopic dermatitis

过敏原免疫疗法和抗生素联合治疗慢性特应性皮炎的概念验证研究

• 批准号: G0701693/1
• 负责人: Graham Ogg
• 金额: $ 39.4万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701693%2F1
• 关键词: Proof; concept; study; combined; allergen

Atopic dermatitis (eczema) affects up to 20% of the UK population and is strongly associated with asthma and hayfever. We have shown that a common skin infection, Staphylococcus aureus, can dramatically alter how the body reacts to harmless environmental proteins or allergens. Therefore individuals are more likely to react to an allergen, such as house dust mite, if they encounter it at the same time as staphylococcal infection. Our findings potentially provide a new mechanism for atopic dermatitis and also for atopic and other allergic diseases, including asthma, hayfever and peanut allergy. We will investigate whether by combining anti-bacterial treatment with allergen desensitisation it is possible to improve symptoms in adult individuals with severe atopic dermatitis. We will also take blood samples from study subjects to examine changes in the immune response during treatment. This will give us important insights into how the disease occurs and how we can improve on our results in future clinical trials.We will present our findings at scientific meetings and through publications, but will also liaise with the public and press whenever appropriate. Dr Graham Ogg has been involved in the presentation of science to the public, for example at the Royal Society Summer Science Exhibition and through the national Public Understanding of Science events and promotes the importance of public engagement in science.

特应性皮炎（湿疹）影响多达 20% 的英国人口，并且与哮喘和花粉症密切相关。我们已经证明，一种常见的皮肤感染金黄色葡萄球菌可以极大地改变身体对无害的环境蛋白质或过敏原的反应。因此，如果个人在葡萄球菌感染的同时遇到过敏原，例如屋尘螨，则更有可能对其产生反应。我们的研究结果可能为特应性皮炎以及特应性和其他过敏性疾病（包括哮喘、花粉热和花生过敏）提供新机制。我们将研究通过将抗菌治疗与过敏原脱敏相结合是否可以改善患有严重特应性皮炎的成年个体的症状。我们还将从研究对象身上采集血液样本，以检查治疗期间免疫反应的变化。这将为我们提供有关疾病如何发生以及如何在未来临床试验中改进结果的重要见解。我们将在科学会议和出版物上展示我们的研究结果，但也会在适当的时候与公众和媒体联络。格雷厄姆·奥格博士一直致力于向公众展示科学，例如在皇家学会夏季科学展览上以及通过全国公众理解科学活动，并宣传公众参与科学的重要性。