Profiling the expressed kinome in patients with early rheumatoid arthritis

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Rheumatoid arthritis affects 1-2% of the UK population and is a chronic debiltating disease with high cost to society. Disease modifying drugs, particularly biological therapies, have had a beneficial clinical and health impact on patients. However, there is a need to discover and develop both more clinically and cost effective treatment options. The study propsoed will allow direct analysis of the targets of new classes of DMARDs in relevant human ex vivo systems to allow more informed clinical development.