THE JOINT ATLAS: A CELLULAR MAP OF KEY ANATOMICAL STRUCTURES IN THE HUMAN SYNOVIAL JOINT DURING DEVELOPMENT AND IN HEALTHY ADULTS.

关节疾病是一个相当大的全球经济负担，在资源充足的卫生系统中，导致残疾的15个主要原因中占5个。然而，在21世纪，我们仍然不知道究竟有多少不同类型的细胞组成一个关节，以及它们在发育和疾病中是如何变化的。微创的出现基于超声的方法来分离和分析组织人类关节结合能力理解的细节所有个体的基因细胞可以表达已经使科学家第一次编译的滑膜地图细胞参与了骨关节炎和类风湿性关节炎等疾病我们现在计划应用相同的技术,我们已经开发出病变组织正常发展和成年组织一起为了组成一个关节“图谱”，将我们所知道的导致疾病的基因与导致多种关节炎组织损伤的细胞联系起来。我们目前所处的阶段是，我们所拥有的最好的联合地图集就像中世纪的世界地图；“世界地图”；我们建议，我们的工作将导致人类关节的“GPS支持谷歌地图”；完全适合我们在21世纪探索，解释和允许开发新的治疗人类关节疾病的方法。

Diseases of the joints represent a considerable global economic burden, accounting for 5 of the top 15 causes of years lived with disability in well-resourced health systems. And yet in the 21st Century we still do not know exactly how many different types of cells make up a joint and how they change during development and in disease. The advent of minimally invasive ultrasound based methods to isolate and analyse tissue from human joints combined with the ability to understand in great details all the genes that an individual cells can express has now enabled for the first time scientist to compile a synovial map of cells involved in diseases such as osteoarthritis and rheumatoid arthritis We now plan to apply the same techniques that we have developed to look at diseased join tissue to normal developing and adult tissue in order to composed a joint "atlas" that can connect the genes that we know cause disease to the cells that are responsible for the tissue damage in many forms of arthritis. We are currently at the stage where the best atlas we have of the joint is like the medieval map of the world; the "mappa mundi"; We propose that our work will lead to a "GPS enabled google map" of human joints; fully fit for us to explore, explain and permit development of new treatments for diseases of the human joint in the 21st century.