THE JOINT ATLAS: A CELLULAR MAP OF KEY ANATOMICAL STRUCTURES IN THE HUMAN SYNOVIAL JOINT DURING DEVELOPMENT AND IN HEALTHY ADULTS.

关节图谱：发育期间和健康成人滑膜关节关键解剖结构的细胞图。

• 批准号: MR/S035850/1
• 负责人: Christopher Buckley
• 金额: $ 58.51万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS035850%2F1
• 关键词: JOINT; ATLAS; CELLULAR; MAP; KEY

Diseases of the joints represent a considerable global economic burden, accounting for 5 of the top 15 causes of years lived with disability in well-resourced health systems. And yet in the 21st Century we still do not know exactly how many different types of cells make up a joint and how they change during development and in disease. The advent of minimally invasive ultrasound based methods to isolate and analyse tissue from human joints combined with the ability to understand in great details all the genes that an individual cells can express has now enabled for the first time scientist to compile a synovial map of cells involved in diseases such as osteoarthritis and rheumatoid arthritis We now plan to apply the same techniques that we have developed to look at diseased join tissue to normal developing and adult tissue in order to composed a joint "atlas" that can connect the genes that we know cause disease to the cells that are responsible for the tissue damage in many forms of arthritis. We are currently at the stage where the best atlas we have of the joint is like the medieval map of the world; the "mappa mundi"; We propose that our work will lead to a "GPS enabled google map" of human joints; fully fit for us to explore, explain and permit development of new treatments for diseases of the human joint in the 21st century.

关节疾病是一个相当大的全球经济负担，在资源充足的卫生系统中，关节疾病占导致残疾的15大原因中的5个。然而，在21世纪的世纪，我们仍然不知道到底有多少不同类型的细胞组成了一个关节，以及它们在发育和疾病中如何变化。基于微创超声的分离和分析人体关节组织的方法的出现，结合详细了解单个细胞可以表达的所有基因的能力，现在首次使科学家能够编制与骨关节炎和类风湿性关节炎等疾病相关的细胞的滑膜图。将关节组织与正常发育和成人组织进行比较，以组成一个关节“图谱”，将我们已知的致病基因与导致多种关节炎组织损伤的细胞连接起来。我们目前正处于这样的阶段，最好的地图集，我们有联合就像中世纪的世界地图;“世界地图”;我们建议，我们的工作将导致“全球定位系统启用谷歌地图”的人类关节;完全适合我们探索，解释和允许开发新的治疗方法的疾病的人类关节在21世纪世纪。

项目成果

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.

• DOI: 10.1016/j.medj.2022.05.002
• 发表时间: 2022-07-08
• 期刊: MED
• 影响因子: 17
• 作者: Korsunsky, Ilya;Wei, Kevin;Pohin, Mathilde;Kim, Edy Y.;Barone, Francesca;Major, Triin;Taylor, Emily;Ravindran, Rahul;Kemble, Samuel;Watts, Gerald F. M.;Jonsson, A. Helena;Jeong, Yunju;Athar, Humra;Windell, Dylan;Kang, Joyce B.;Friedrich, Matthias;Turner, Jason;Nayar, Saba;Fisher, Benjamin A.;Raza, Karim;Marshall, Jennifer L.;Croft, Adam P.;Tamura, Tomoyoshi;Sholl, Lynette M.;Vivero, Marina;Rosas, Ivan O.;Bowman, Simon J.;Coles, Mark;Frei, Andreas P.;Lassen, Kara;Filer, Andrew;Powrie, Fiona;Buckley, Christopher D.;Brenner, Michael B.;Raychaudhuri, Soumya
• 通讯作者: Raychaudhuri, Soumya

A transcriptomic census reveals that Rbfox contributes to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus

转录组普查表明，Rbfox 有助于胸腺中周围组织剪接模式的广泛但选择性的重演

• DOI: 10.1101/2020.03.06.980870
• 发表时间: 2020
• 作者: Jansen K

Mesenchymal cells in health and disease.

健康和疾病中的间充质细胞。

• DOI: 10.1038/s41590-022-01318-8
• 发表时间: 2022
• 期刊: Nature immunology
• 影响因子: 30.5
• 作者: Koliaraki V

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.

• DOI: 10.1101/gr.275245.121
• 发表时间: 2021-11
• 期刊: Genome research
• 影响因子: 7
• 作者: Jansen K;Shikama-Dorn N;Attar M;Maio S;Lopopolo M;Buck D;Holländer GA;Sansom SN
• 通讯作者: Sansom SN

A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

• DOI: 10.1038/s41467-024-45341-9
• 发表时间: 2024-02-19
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Ng，Michael T. H.;Borst，Rowie;Dakin，Stephanie G.
• 通讯作者: Dakin，Stephanie G.