Biomarkers to predict severity in dengue infection

登革热是热带和亚热带地区的一种蚊媒病毒感染。它可能导致严重的出血热，除非在医院治疗，否则可能致命。在早期阶段，不可能判断哪些患者会出现更严重的症状，应该住院治疗。在流行病期间，几乎可以同时发生数千例病例，使医院系统完全不堪重负。这项研究的目的是开发一种简单的疾病严重程度预测器，允许高风险患者住院，而风险较低的患者可以在家中进行管理。

Dengue is a mosquito bourne viral infection of the tropics and subtropics. It can lead to a severe haemorrhagic fever that can be fatal unless treated in hospital. At the early stages it is impossible to judge which patients are going to suffer the more severe symptoms and should be admitted to hospital. During epidemics literally thousands of cases can occur at the same time and completely overwhelm the hospital systems. This research aims to develop a simple predictor of disease severity which would allow the high risk patients to be admitted to hospital whilst those at lower risk could be managed at home.