Biomarkers of clinical transplantation tolerance

临床移植耐受的生物标志物

• 批准号: G0801537/1
• 负责人: Robert Lechler
• 金额: $ 144.6万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801537%2F1
• 关键词: Biomarkers; clinical; transplantation; tolerance

Kidney transplant recipients need to be treated with drugs that hold down the immune system (immunosuppression) for life. These drugs have important side effects and we currently don?t have means to know how much treatment each patient needs.We have recently defined a series of tests that may allow us to identify which kidney transplant recipients do not reject their grafts when taken off immunosuppression. These are very preliminary results. We need to perform several studies to confirm them. Thus, we are proposing to repeat the study in new groups of patients. If validated our tests could be used to safely minimise or remove immunosuppression in those kidney transplant recipients that don?t need it.

肾移植受者需要终身接受抑制免疫系统（免疫抑制）的药物治疗。这些药物有重要的副作用，我们目前不？我们没有办法知道每个病人需要多少治疗，我们最近确定了一系列的试验，这些试验可能使我们能够确定哪些肾移植受者在解除免疫抑制后不会排斥移植物。这些都是非常初步的结果。我们需要进行几项研究来证实它们。因此，我们建议在新的患者组中重复这项研究。如果得到证实，我们的测试可用于安全地减少或消除那些肾移植受者的免疫抑制？我不需要。