The role of individual isoforms of p38 mitogen-activated protein kinase in myocardial infarction

p38 丝裂原激活蛋白激酶的各个亚型在心肌梗死中的作用

• 批准号: G0802033/1
• 负责人: Michael Marber
• 金额: $ 79.96万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802033%2F1
• 关键词: role; individual; isoforms; p38; mitogen

Blockage of a coronary artery causes a heart attack. This decribes the symptoms caused by the death of the heart muscle downstream of the blockage. We are intersted in preventing the death of this muscle by studying the role of proteins known as p38 mitogen-activated protein kinases. These proteins aggravate muscle death and also cause on-going heart damage that can lead to heart failure.

冠状动脉阻塞会导致心脏病发作。这描述了由阻塞下游的心肌死亡引起的症状。我们有兴趣通过研究称为p38丝裂原活化蛋白激酶的蛋白质的作用来防止这种肌肉的死亡。这些蛋白质会加剧肌肉死亡，并导致持续的心脏损伤，从而导致心力衰竭。