IDENTIFYING CARDIAC SUBSTRATES OF p38alpha MITOGEN-ACTIVATED PROTEIN KINASE

鉴定 p38α 丝裂原激活蛋白激酶的心脏底物

• 批准号: MR/J007501/1
• 负责人: Michael Marber
• 金额: $ 60.96万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ007501%2F1
• 关键词: IDENTIFYING; CARDIAC; SUBSTRATES; p38alpha; MITOGEN

During cardiac stress an enzyme known as p38alpha mitogen-activated protein kinase (p38) becomes active. The purpose of the p38 enzyme is to alter the function of proteins by adding phosphate to them. In many cases this helps cells respond to stress. However it is clear that under some circumstances p38 activation worsens injury. The fact that activation of p38 can have both good and bad consequences may explain why clinical trials of p38 inhibition have not yet shown benefit. The purpose of this project is to create mutations within p38 that subtly alter its enzyme activity. These mutations mean that it is possible to trace the proteins to which p38 has added a phosphate. This will allow us to identify the individual proteins modified by p38 and work out which changes help cells respond to stress and which worsen injury. Ultimately this knowledge may enable refined therapies that help cells respond to stresses such as the myocardial infarction that follows coronary artery thrombosis.

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项目成果

p38 MAPK in cardioprotection - are we there yet?

• DOI: 10.1111/bph.12901
• 发表时间: 2015-04
• 期刊: British journal of pharmacology
• 影响因子: 7.3
• 作者: Martin ED;Bassi R;Marber MS
• 通讯作者: Marber MS

p38? MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.

p38？

• DOI: 10.1096/fj.201701545r
• 发表时间: 2019
• 期刊: official publication of the Federation of American Societies for Experimental Biology
• 作者: Loonat AA