The validation of cMyBP-C as a new diagnostic marker of myocardial infarction

cMyBP-C作为心肌梗死新诊断标志物的验证

• 批准号: G1000737/1
• 负责人: Michael Marber
• 金额: $ 52.45万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000737%2F1
• 关键词: validation; cMyBP; new; diagnostic; marker

Only a small proportion of patients with chest pain have acute myocardial infarction (MI). Although the ECG provides a very useful immediate test often patients have to be admitted in order to be sure they are not having an MI. The diagnosis of MI is made by the release of cardiac proteins known as troponins. These proteins are released slowly into the blood and also disapear slowly from the blood. The consequence is that patients need to be kept in hospital for at least 12 hours to make sure troponins do not appear in their blood. Furthermore once they do appear, and a diagnosis of MI is made, it can be difficult to know if patients are having further MIs because the troponins stay elevated after the first MI. The purpose of this application is to determine if another cardiac protein, known as cardiac myosin binding protein C, is released more quickly and/or cleared more quickly than troponin.

只有一小部分胸痛患者患有急性心肌梗塞(MI)。虽然心电图提供了一种非常有用的即时测试，但患者通常必须入院以确保他们没有心肌梗死。心肌梗死的诊断是通过释放被称为肌钙蛋白的心脏蛋白来做出的。这些蛋白质缓慢地释放到血液中，也慢慢地从血液中消失。其结果是，患者需要在医院至少呆12个小时，以确保他们的血液中不会出现肌钙蛋白。此外，一旦肌钙蛋白出现，并被诊断为心肌梗死，就很难知道患者是否有进一步的心肌梗死，因为肌钙蛋白在第一次心肌梗死后保持升高。这项应用的目的是确定另一种被称为心肌肌球蛋白结合蛋白C的心脏蛋白是否比肌钙蛋白更快地释放和/或清除。