High resolution, high field strength MRI studies of the mechanisms and architecture underlying human stereoscopic vision

高分辨率、高场强 MRI 研究人类立体视觉的机制和结构

• 批准号: G0802171/1
• 负责人: Holly Bridge
• 金额: $ 47.56万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802171%2F1
• 关键词: resolution; field; strength; MRI; studies

Functional magnetic resonance imaging (fMRI) can be used to visualise activity in the brains of human subjects. When a region of the brain becomes active the cells begin to fire action potentials to communicate information. An increased flow of oxygen is required in that local region to fuel this activity. Since oxygenated (fresh) and de-oxygenated blood have different magnetic properties, it is possible to use the ratio of these two substances to measure changes in brain activity. The techniques used for looking at the human brain, both its function and its connections, are constantly evolving, allowing us to gain more and more information.This project is designed to determine how we use our 2 eyes to see in depth. There are many pieces of information that can tell us where objects are in relation to each other, but if a slight difference is introduced between the images of the two eyes artificially, such as in ?Magic Eye? pictures, an object may ?jump? out without any other information available. Using stimuli that are similar to Magic Eye pictures we will investigate 3 main issues:1) We will look in the normal population to see whether different areas of the brain are specialised for processing different stages of depth perception. We will also investigate whether the responses of the brain are related to how good people are at seeing depth. 2) Deficits in depth perception are common, as any misalignment of the two eyes during early childhood due to ?squint? or ?lazy eye? can prevent the development of binocular neurons; those sensitive to input from both eyes. Although these conditions can often be corrected surgically, not all children regain their binocular vision. We will investigate the neural responses in such subjects lacking binocular vision to examine how their brains process information differently from people with normal binocular vision.3) The amount of detail that can be seen with fMRI depends on various factors, but an important one is the strength of the magnet used for the experiments. We are very fortunate in Oxford as we will have access to a very strong magnet that we will use to investigate the very fine organisation believed to underlie the perception of depth.

功能性磁共振成像（fMRI）可用于可视化人类受试者大脑中的活动。当大脑的某个区域变得活跃时，细胞开始激发动作电位来传递信息。在该局部区域中需要增加的氧气流量来为这种活动提供燃料。由于含氧（新鲜）和脱氧血液具有不同的磁性，因此可以使用这两种物质的比例来测量大脑活动的变化。用于观察人类大脑的技术，无论是其功能还是其连接，都在不断发展，使我们能够获得越来越多的信息。这个项目旨在确定我们如何使用我们的双眼来深入观察。有许多信息可以告诉我们物体之间的关系，但是如果在两只眼睛的图像之间人为地引入轻微的差异，比如在？魔眼？图片，一个对象可以吗？跳下去？没有任何其他可用的信息。使用类似于魔术眼图片的刺激，我们将研究3个主要问题：1）我们将在正常人群中观察大脑的不同区域是否专门用于处理深度感知的不同阶段。我们还将研究大脑的反应是否与人们在深度方面的表现有关。2)深度知觉的缺陷是常见的，因为在儿童早期，由于？斜眼？还是？弱视？可以阻止双眼神经元的发育;那些对双眼输入敏感的神经元。虽然这些情况通常可以通过手术矫正，但并非所有儿童都能恢复双眼视觉。我们将研究缺乏双眼视觉的受试者的神经反应，以检查他们的大脑如何与正常双眼视觉的人不同地处理信息。3）功能磁共振成像可以看到的细节取决于各种因素，但重要的是用于实验的磁铁的强度。我们在牛津大学非常幸运，因为我们将有机会获得一个非常强大的磁铁，我们将用它来研究被认为是深度感知的基础的非常精细的组织。